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I was recently prescribed OC and my ortho was kind (or smart) enough to relise that it may only last 6 hours. I was given enough to take 1 every 6 hours with 7.5 Percs for breakthrough. I took an ambulace ride to the er for him to see I was in real trouble but at least I'm getting the relief I need. There is no way I could go 12 hours on one tab. I would be writhing in pain by then.....