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I could be wrong, but I think this is what they did with Talwin several years ago. Now it's Talwin NX and if you crush it the naloxone or naltrexone (whichever the NX is), the full antagonist with a wicked binding affinity, is released and the drug effect is null and void. They're working on the same for oxycontin right now too, FWIW.
L
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