AngelWolf13
Enthusiast
Reged: 07/07/04
Posts: 258
Loc: w/ my '91 CE-24 in SoCal....
|
|
i just posted this article in response to a member in another thread but i think that perhaps this deserves it's own thread. it is an article i found on MedicineNet.com
here is the link...
http://www.medicinenet.com/script/main/art.asp?articlekey=38688
here's the article.....
Quote:
Vioxx or Celebrex, Which is Safer?
A study of people enrolled in the Kaiser Permanente health plan reportedly found that heart attack rates and sudden cardiac deaths were tripled in patients taking Vioxx in doses higher than 25 milligrams a day compared to those taking a competing drug, Celebrex. The study was done by personnel at the FDA, who said that "this and other studies cast serious doubt on the safety" of Vioxx and that Celebrex "may be safer."
Comments: We do not know what to make of this story. It has not appeared in a peer-reviewed medical journal to our knowledge nor has it been published in any other form. We tried and could not find it on the FDA site (or on the Kaiser Permanente site). We would like to see a report of the study so that we can evaluate it.
We also do not understand how FDA personnel can say that Celebrex "may be safer." It seems highly unprofessional for the FDA, if they did, to enter into the competition between these two popular drugs for arthritis.
This story looks to be a case of preliminary medical information dispensed at a press conference. The FDA should come clean and issue a proper warning and back it up with the facts.
Barbara K. Hecht, Ph.D.
Frederick Hecht, M.D.
Medical Editors, MedicineNet.com
don't want to start a panic especially as i really don't know what or who to believe yet, but i just want everyone to be aware of the possibilities. i quit taking celebrex long before i read this article. to all, be safe.
c.(angel)
--------------------
"Some mornings, it's just not worth chewing through the leather straps."
Emo Philips.
|
ordberger
Stranger
Reged: 03/26/04
Posts: 20
|
|
Celebrex and bextra both stop the heart protecting prostaglandins (sp?) and so some of the doctors that study these medications believe that the problem may be universal.
|
qbird
material girl
Reged: 09/02/02
Posts: 812
Loc: USA
|
|
So you are saying Celebrex is not safe either? Oh no, I have to take it due to a recent back injury.
|
Lablady2
Member
Reged: 05/05/04
Posts: 169
Loc: New York City
|
|
I would bet my last dollar on the fact that Celebrx and the other Cox inhibitors are going to be yanked next. The big pharms are now really scared of the humongous lawsuits coming their way. Already in this AM's Sunday paper there are about 10 advertisements from law firms aimed at people who have taken Voixx.
Having worked in pharmaceuticals and know how this "works" - I will also bet my bottom dollar on the fact that Merck knew from day one that there were big potential problems with this drug. However, it is another big "me too" moneymaker - very little invested in R&D for this type of drug vs the potential for a huge moneymaker. Clinical studies were in all probability "fudged" and FDA as usual looked the other day.
This is one reason I am SO angry about the BS of cracking down on OP's and IOP's saying overseas drugs are NOT safe. They are no more nor no less safe than what you can get an RX here for - just more government hypocracy and pandering to the big pharm firms who need a thorough housecleaning along with the FDA - or the fox that watches the henhouses.
|
ML63
Member
Reged: 02/08/03
Posts: 169
Loc: Upstate New York
|
|
Quote:
So you are saying Celebrex is not safe either? Oh no, I have to take it due to a recent back injury.
A lawyer friend of mine just recorded a TV commercial urging Vioxx users to call him so he can "help them". He told me that he also has a Celebrex version of the commercial in the can just in case. Then again, I've been seeing Celebrex commercials all weekend on my basic cable system. Big drug companies can be scum, but I have a hard time believing that even they would continue to air commercials if a recall was immenent. I mean, talk about a self inflicted black eye. IMO, the Celebrex folks probably feel safe for the time being.
|
Daeshay76
Board Addict
Reged: 03/22/04
Posts: 375
|
|
isnt both vioxx and celebrex in the same family of theraputic class? IMO celecrex will be pulled as well but thats just my thoughts on this.
|
pecan
Enthusiast
Reged: 09/09/03
Posts: 264
Loc: KINDA N.W.
|
|
I looked Vioxx up on rxlist.com and it has celebrex right along with it. You can look for yourselves, but I think it is the same. Anyway I took it away from my husband.
--------------------
pecan
|
oothibo
Newbie
Reged: 07/13/04
Posts: 28
|
|
Vioxx and Celebrex are basically the same thing. They are both Cox-2 inhibitors. Bextra is also a related drug. Everyone thought that these were much safter then general COX inhibitors (which target both COX-1 and COX-2) because they do not have an impact on platelet aggregation and they are more protective on the gastrointestinal tract.
I would bet that those who took Vioxx, if they looked on their prescription warning sheets (given by the pharmacy) there was probably some kind of warking thta the COX-2 inhibitors can cause a higher incidence of cardiovascular thrombotic events. The reason I say this is because it is stated in my pharmacology book (which was published 2 years ago). So, it was known there was a risk with taking these agents.
I have to say that any pharmaceutical you choose take poses a possible risk to your health. Many advise not to take new medications that come to market for the first 7 years they are available because the side effects are not always known. Yeah, there are years of clinical trials and the FDA has mandates on what is safe and what is not but unfortnately there is no better alternative and most of the time the study size isn't as large as it should be and it isn't given the adequate amount of time.
Unfortunately, that is the price we pay for the advancements we make in medical/pharmaceutical industries.
|
MWouk
Journeyman
Reged: 08/28/03
Posts: 82
Loc: Up & Down I - 95
|
|
This warning was not on my list of problems or side effects of the drug printed on the sheet the pharmacist includes in the bag. However I recollect a warning issued about 2 years ago that advised patients who take Vioxx to take a daily aspirin with Vioxx if they were depending on it to act as other NSAIDs which thin the blood, because Vioxx has been shown to allow blood to clot easily.
What I did notice that popped up on the pharmacy's sheet listing recommendations, only recently, is that one should remain sitting or standing (do not lie down) for 30 minutes after ingesting it, something people are advised to do to prevent damage to esophagus. I think this same warning is a "sticky" on the side of a bottle of Fosamax, and episodes of GERD can be prevented this way.
--------------------
MWouk
|
Previous
Index
Next
Threaded
Edit 
Reply 
Quote 
