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its a few references to the fact that tramadol causes serotonin release, which i believe it does as well from my own subjective experience. however i must note that at least for me, its more of an opioid than anything else.
Those with extensive 2D6 metabolism will benefit the most from tramadol, especially those with multiple copies of the 2D6 Gene. Those who are deficient in CYP2D6 are most likely to have an adverse reaction to it and the least benefit.