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FYI, opiates lower blood sugar. A cigarette temporarily raises it, then causes it to go lower than it was before- which is why you tend to chain-smoke on opiates if you're a smoker.
I've lost weight since being on opiates, which I attribute to less appetite. Don't know how much, it was enough for me to notice it, maybe 8-10 pounds.
And when I was on Zoloft, I lost weight too- which I hear is unusual. I really didn't like Zoloft- very much flattened out my moods (couldn't be happy, couldn't be sad- was just even; I imagine this is a good thing if you're very severely depressed). It obliterated my appetite, I was eating an apple or some kind of fruit for lunch and a small dinner- and wasn't bothered by it. Also did the same thing for my sex drive. Very happy to be off that drug.