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I watched many people who enrolled in the methadone maintenance program go from being little twigs to grossly obese while I spent my 7 years on it.
I would suspect that the consistently radical weight gain among those specific folks may be highly attributable to the fundamental lifestyle change that occurs for many upon entering methadone maintenance whose lifestyle, finances, and daily routine may no longer focus on "scoring", or even more diligently, trying to not get "sick" at the expense of many things, including nutrition.