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my best guess is that proglumide would be a safer and less dependance increasing enhancer than inhibiting CYP metabolism, since its just a CCK Peptide inhibitor. it wouldn't increase blood levels of the opioid, but rather hinder ONE mechanism of tolerance, the build up of CCK peptide, which is the body's anti-opioid. but there is no study i know of comparing the safty of the two.
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Also, any chance it would potentiate tramadol? I'm guessing "no", but can't hurt to ask.
Im guessing yes, it would, because part of tramadol's mechanism is the same as any other painmed, Mu Opioid Agonist. For me tramadol is very much an opioid but i think i have extensive 2D6 metabolism and metabolize a lot into M1. Tramadol's M1 metabolite is 200 times more of an opioid than tramadol it's self. the other metabolites, generated by 3A4, are almost inactive in comparison according to my research.
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Re: Brent's Guide to Proglumide Therapy
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