DrugBuyers.Com: Brent's Guide to Proglumide Therapy

Proglumide Therapy v1.0 - 11/07/2004

I will to my best to rewrite this guide, since it was lost after PW's problems with their ISP, so here goes. I was inspired to write this guide thanks to Missthang, and a few others who IMed me with questions about Proglumide. Several years ago I was having kidney stones, with painful urinary colics in between. I was taking 12-15 10mg of hydrocodone a day for almost 6 months, and I was able to reduce my tolerance to hydrocodone considerably (from 12 down to 5 for myself). Currently, The Dispensary sells a 30 pack of 400mg Proglumide for 68 bucks, which is more than enough for one "session" of Proglumide therapy, which is 5 weeks (21 pills total for one session). The pills will be broken in half, so one pill will be used a day. As for my credentials, I am a registered nurse, currently striving to achieve my CRNA (Certified registered nurse anesthesist).

Proglumide source: http://the-dispensary.com/comfiles/pages/141.shtml

Day 1-7
When you wake up: Start out the morning by taking 200mg of Proglumide, along with 75% of your normal hydrocodone dosage. Trust me, this is all you will need with the Proglumide...it's that good.
During the day: Take your normal dosages of hydrocodone, but try to skip one dosage through out the day. It's not going to be hard, since the Proglumide makes the hydrocodone last longer and work a lot more. (Example: Say you are taking 2 pills, 5 times a day. Try to eliminate one dosage where you would take 2 pills, 4 times a day.)
When you go to sleep: Before you're about to go to bed, take the other 200mg of Proglumide, along with 75% of your normal dosage of hydrocodone. Also, take an antihistamine such as Atarax/Vistaril (hydroxyzine) or Benadryl, or a stomach acid medicine such as Zantac or Tagamet. This will help to boost the hydro at night when you are asleep so you will be able to sleep throughout the night with out any disturbances.

Day 8-14
This week you won't be taking any Proglumide, because you can develop a tolerance to Proglumide as well...and we definitely do not want this to happen. By this time, you should be able to eliminate one of your dosages during the day now. (Example: Whereas you were taking 10 hydrocodone pills a day, you should now be able to make it with 8.) If you have a flareup with pain, try not to take any more hydrocodone. Boost it with an antihistamine or acid reducer as mentioned above. If nothing else will help the pain, you may take more hydrocodone. Remember, we're only trying to reduce your tolerance, not make you feel miserable; this is why we're on the painkillers in the first place!

Day 15-21
Repeat cycle from first week, etc.

As mentioned, one "session" is five weeks long, three of which you will be taking the Proglumide. This is a really effective drug for reducing your tolerance to hydrocodone, or any other painkiller for that matter. With this relatively simple guide you should be able to do just that. You may repeat the cycle again in approx. 2-3 months for reducing your opiate tolerance even more. I used 3 cycles of Proglumide therapy and was able to recide my tolerance by at least 50% after the third cycle.

I hope this guide can at least be a stepping stone for people who are interested in Proglumide therapy. If you have any questions, feel free to PM them my way, as I frequent this board several times a day. Hopefully this will benefit others, since everyone on PW has helped me out so much since I've been a member. Most of all, GOOD LUCK!

--bmurphr1