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i have been Rxed both the hydro 10/325 and percs 10/325 by my pain clinic and i can not tell the difference in either. i can not tell that the percs are any stronger than the hydro but thats just me. could it be that i have been on pain meds for so many years? i am also taking 60mg of avinza twice daily and the percs for break-through and i have no relief at all....any suggestions on what i can ask the doc for on my next appointment for long acting and for breakthrough that may be a little stronger and more helpful for my pain? i suffer from fibro and diabetic problems....TIA