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Is what everybody is referring to as NAC, N-Acetyl-Cystine? If so then NAC is better known as MucoMyst and happens to be what is given to patients w/ APAP overdose. It would not affect hydro in essence, but Glutathione might in that Glutathione is what the liver uses to conjugate APAP (and alcohol) in order to prevent free-radicals and peroxidation (and resultant liver damage).