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The idea behind NAC is for it to turn into l-cysteine, which then turns into glutathione. Glutathione is what gets depleted by OD'ing on APAP.
All you need is NAC. Glutathione taken orally isn't very well absorbed, but it couldn't hurt. Neither could extra vitamins. Will they have any effect beyond what NAC is doing all by itself? I really doubt it.
I don't really believe in Milk Thistle myself, I only take NAC with every dose of APAP-containing pain meds, and I've never had an abnormal liver profile.
Just keep in mind there is a lot of conflicting information about all this, made worse by herbal "experts" trying to sell you something. The articles I've read from reliable sources don't mention anything other than NAC, though sometimes glutathione in combination is mentioned.