lowell
Stranger
Reged: 08/01/02
Posts: 16
Loc: Northeast
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Hey there! I am thinking of doing a total detox from tramadol. (by the way....I have heard of folks having siezures from tramadol....have you?)
My current plan is to use
Immodium Ad
Kratom
and maybe a little diazepam
Does anyone know of anything else that might really help?
In spite of the pain I need to detox from this stuff!
I kmow you are some long time members out there who have experience with tramadol....any and all advice is greatly appreciated!
Thanks!
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tone
Veteran
Reged: 06/29/03
Posts: 529
Loc: Chicago
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what is your daily dose?
also add a little 5-HTP to that list, just a little theres no need to take full 50 mg pills of it. part of the withdrawal maybe serotonin depletion as tramadol does force some release.
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theborg
Enthusiast

Reged: 10/20/02
Posts: 294
Loc: Boston
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I would suggest some Phenergan. It's a anti-nausea medication.
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Forget your fears and want no more
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Julz
Enthusiast
Reged: 11/17/03
Posts: 222
Loc: NJ Shore
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lowell~
From what I've read from various boards, Tramadol wd's are pretty bad. You may want to consider tapering instead of going cold turkey. I have posted what is called the "Thomas Recipe" that you may want to consider along with what you already have planned. Here it is:
The Thomas Recipe:
For the Recipe, You'll need:
1.A Benzodiazepine such as Klonopin, Librium, Ativan or Xanax). Of these, Valium and Klonopin are best suited for tapering since they come in tablet form.
2. Imodium (over the counter, any drug or grocery store).
3. L-Tyrosine (500 mg caps) from the health food store.
4. Strong wide-spectrum mineral supplement with at least 100% RDA of Zinc, Phosphorus, Copper and Magnesium.
5. Vitamin B6 caps.
6. Access to hot baths or a Jacuzzi (or hot showers if that's all that's available).
How to use the Recipe:
Begin your detox with regular doses of Valium (or alternate benzo). Start with a dose high enough to produce sleep. Before you use any benzo, make sure you're aware of how often it can be safely taken. Different benzos have different dosing schedules. Taper your Valium dosage down after each day. The goal is to get through day 4, after which the worst WD symptoms will subside. You shouldn't need the Valium after day 4 or 5.
During detox, hit the hot bath or Jacuzzi as often as you need to for muscle aches. Don't underestimate the effectiveness of hot soaks. Spend the entire time, if necessary, in a hot bath. This simple method will alleviate what is for many the worst opiate WD symptom.
Use the Imodium aggressively to stop the runs. Take as much as you need, as often as you need it. Don't take it, however, if you don't need it.
At the end of the fourth day, you should be waking up from the Valium and experiencing the beginnings of the opiate WD malaise. Upon rising (empty stomach), take the L-Tyrosine. Try 2000 mgs, and scale up or down, depending on how you feel. You can take up to 4,000 mgs. Take the L-Tyrosine with B6 to help absorption. Wait about one hour before eating breakfast. The L-Tyrosine will give you a surge of physical and mental energy that will help counteract the malaise. You may continue to take it each morning for as long as it helps. If you find it gives you the "coffee jitters," consider lowering the dosage or discontinuing it altogether. Occasionally, L-Tyrosine can cause the runs. Unlike the runs from opiate WD, however, this effect of L-Tyrosine is mild and normally does not return after the first hour. Lowering the dosage may help.
With breakfast, take the mineral supplement.
As soon as you can force yourself to, get some mild exercise such as walking, cycling, swimming, etc. This will be hard at first, but will make you feel considerably better.
Good luck and God bless!
Peace,

Julz
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Love never fails. 1Cor 13:8
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efffbeee
Member
Reged: 10/22/02
Posts: 115
Loc: usa
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Quote:
what is your daily dose?
also add a little 5-HTP to that list, just a little theres no need to take full 50 mg pills of it. part of the withdrawal maybe serotonin depletion as tramadol does force some release.
it doesn't "force release" of seretonin at all. it is a mild seretonin (and norepinephrine) reuptake inhibitor. but i agree, 5htp could help. also, i suggest trying out l-tyroise and dl-phenylalanine and seeing which one works better. most people find that one is better than the other but opinions vary a lot. its probably not good to take both at the same time though.
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TTFREE
Newbie
Reged: 11/29/04
Posts: 40
Loc: MD USA
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Wow so thats the Thomas Receipe
Good To Know !!
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Chance Favors the Prepared Mind !
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tone
Veteran
Reged: 06/29/03
Posts: 529
Loc: Chicago
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yes it does, look it up. its not in the official prescribing info but its in other studies
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tone
Veteran
Reged: 06/29/03
Posts: 529
Loc: Chicago
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Quote:
it doesn't "force release" of seretonin at all. it is a mild seretonin (and norepinephrine) reuptake inhibitor.
"Basal serotonin release was preferentially enhanced by the (+) enantiomer and stimulation-evoked norepinephrine release was preferentially enhanced by the (-) enantiomer."
-Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL, Jacoby HI, Selve N
R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania.
J Pharmacol Exp Ther 1993 Oct;267(1):331-40
http://members.aol.com/fibroworld/ultram2.htm
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"Tramadol may also induce serotonin release, particularly at higher concentrations."
- Serotonin Syndrome Resulting from Coadministration of Tramadol, Venlafaxine, and...
Houlihan Ann Pharmacother.2004; 38: 411-413.
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" Although the precise mode of action is unclear, the analgesic properties of tramadol appear to result partly from an action on opioid receptors, and partly through inhibition of noradrenaline re-uptake and enhanced serotonin release."
- http://medicines.mhra.gov.uk/ourwork/monitorsafequalmed/currentproblems/cp11.htm
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"Individual vulnerability appears to play a role in the development of SS. It is likely that the activation of 5-HT(1A) receptors by mirtazapine, the combined serotonin reuptake inhibition by venlafaxine and tramadol, as well as possible serotonin release by tramadol, contributed to the development of SS in this case."
- http://www.ncbi.nlm.nih.gov/entrez/query...4&dopt=Abstract
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therhino
Enthusiast
Reged: 06/06/04
Posts: 223
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Quote:
Quote:
it doesn't "force release" of seretonin at all. it is a mild seretonin (and norepinephrine) reuptake inhibitor.
"Basal serotonin release was preferentially enhanced by the (+) enantiomer and stimulation-evoked norepinephrine release was preferentially enhanced by the (-) enantiomer."
-Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL, Jacoby HI, Selve N
R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania.
J Pharmacol Exp Ther 1993 Oct;267(1):331-40
http://members.aol.com/fibroworld/ultram2.htm
----
"Tramadol may also induce serotonin release, particularly at higher concentrations."
- Serotonin Syndrome Resulting from Coadministration of Tramadol, Venlafaxine, and...
Houlihan Ann Pharmacother.2004; 38: 411-413.
----
" Although the precise mode of action is unclear, the analgesic properties of tramadol appear to result partly from an action on opioid receptors, and partly through inhibition of noradrenaline re-uptake and enhanced serotonin release."
- http://medicines.mhra.gov.uk/ourwork/monitorsafequalmed/currentproblems/cp11.htm
----
"Individual vulnerability appears to play a role in the development of SS. It is likely that the activation of 5-HT(1A) receptors by mirtazapine, the combined serotonin reuptake inhibition by venlafaxine and tramadol, as well as possible serotonin release by tramadol, contributed to the development of SS in this case."
- http://www.ncbi.nlm.nih.gov/entrez/query...4&dopt=Abstract
so what does this mean to the common man?
thanks for your effort!
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spellcheckers are like wearing ties, I just say no :-)
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tone
Veteran
Reged: 06/29/03
Posts: 529
Loc: Chicago
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its a few references to the fact that tramadol causes serotonin release, which i believe it does as well from my own subjective experience. however i must note that at least for me, its more of an opioid than anything else.
Those with extensive 2D6 metabolism will benefit the most from tramadol, especially those with multiple copies of the 2D6 Gene. Those who are deficient in CYP2D6 are most likely to have an adverse reaction to it and the least benefit.
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