redhill
Banned. Flames, offending others
Reged: 06/02/03
Posts: 278
Loc: Hell on Earth, for now
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As with any new topic/drug, it's a nightmare just figuring out to which forum to post this, so let's just keep our fingers crossed that this is posted to the appropriate one.
Endo seems to be busy developing two new formulations of their existing painkiller (and a strong one at that): Numorphan.
I will post the link to an article I found on it. I hope it'll spark some lively discussion as well as curiosity and, hopefully, more information in the future.
Meanwhile, let me pose a few questions/ideas for discussion:
1) With the possibility of Numorphan eventually becoming more widely available, does anyone think that comparitively weaker drugs such as OxyContin will attract less media scrutiny? And therefore be easier to obtain from the doctor?
2) Will Numorphan become the new "hillbilly heroin"?
3) Will all painkillers be exceedingly tough to get, including OxyContin, Numorphan, and even Codeine?
4) How much more restrictive can the existing rules get?
Here's the link to the story I saw:
Forbes magazine article on Oxymorphone
raw link for the click-challenged:
http://www.forbes.com/markets/newswire/2004/03/31/rtr1319524.html
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yawkaw3
Pooh-Bah
Reged: 03/22/03
Posts: 1193
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1) Nope and Nope. I think that XR Numorphan is going to be mainly for opiate-dependent patients, like people who have already been on Oxy and Duragesic and now need something stronger. Of course they could make all kinds of dosages and satisfy a wider variety of patients like Oxy does, but I think it would be too hard to compete with all the big players already in that market. Aside from that, I just don't think this drug will be popular enough to take any of the heat off of Oxy, especially with generic Oxy coming our way.
2) It certainly will be popular amongst junkies and recreational users. Let's pray people don't get stupid with it and high school kids respect how strong this stuff can potentially be. I think it will have its own clique of users, but I don't think it will be popular or widespread enough for it to be as demonized as OxyContin is and was.
3) In the forseeable future, I do think painkillers will be slightly tougher to get. But I also think that restrictions will ease some day (10-20 years?) on all drugs. I don't know that the War on Pain will ever be over before that time, but I think the War on Pot will be by then.
4) I think the existing rules will get slightly tougher and then gradually ease up over the next decade.
-yawkaw
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harley88
Member
Reged: 06/17/03
Posts: 174
Loc: WV
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Numorphan has been marketed in the U.S. before .I,m not sure how long ago they quit selling it here in the U.S. They were blue tablets .I can,t remember the mg. of the tablet form of it .They later took the tablet form of it off the U.S. market and only had the liquid form of it for surgical purposes .I have a older PDR with the liquid form desqription in it. We used to call it blue morphine on the street .This was about 30 years ago.
harley88
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"Playing the blues and nothing but the blues"
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yawkaw3
Pooh-Bah
Reged: 03/22/03
Posts: 1193
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NuMorphan has been around for a very long time. But now Endo is making an extended release version like NuMorphanContin (heh, probably it sounds more poetic than that, whatever name they pick). Now an already powerful drug will be available in a much higher strength. A lot of companies are doing this, selling XR versions of a drug that has lost its patent protection (Xanax XR, for example).
-yawkaw
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redhill
Banned. Flames, offending others
Reged: 06/02/03
Posts: 278
Loc: Hell on Earth, for now
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Meanwhile, what's up with the development of Palladone?
And why is it taking so long? Canada, the UK, France, Belgium, Holland, Germany and probably more countries have had both the IR and ER versions for many many years.
I already know that the FDA relies on kickbacks to approve new drugs  in the USA, but then again, we've had Dilaudid here for a while?
The compound is tried and tested, so why should the formulation be such a stumbling block?
I know they seem impossible to please, and their rules are tight, and many a drug in development has been sent back to the drawing board. Got to be frustrating for the poorer pharmaceutical companies that have already sunk, oh, $30 million into r&d. I'd say it can make or break some companies, and allow the FDA to pick and choose whom they want to survive. Don't like company Y because, say, they're French?  (imagine dun! dun! DUN! scary film score-like music). Well, let's pick on a few faults here, a form not filled out correctly there, and send them back while Pfizer or Eli Lilly make off with the grand prize. Not that most Euro companies don't know exactly how to play the game, though...
Am I seeing this incorrectly? I probably am, but would like to know how and why. Anybody have any insight into the inner workings of the FDA? I am particulary interested in how it is that they can influence drug policy abroad, such as in the case of Survector and Reboxetine.
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brutus
Enthusiast
Reged: 09/05/02
Posts: 235
Loc: MIDWEST
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I guess its astupid Q to ask if those countries that have had it for a while have OP's that offer it w/records??
Had to ask
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Brutus
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jamison
Stranger
Reged: 11/08/04
Posts: 2
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DOES ANYONE KNOW WHEREI CAN SCORE PALLADONE ONLINE
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TwG
Journeyman
Reged: 06/17/02
Posts: 70
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This drug is just like morphine, heroin, and hydromorphone, it needs to be injected for the full effect, most OC users don't do this so it will never get as big as OCs, if they make it uninjectible it will blow, just like MS-Contins and generic hydromorphone. Also, remeber that the media made OCs big, just like why noone knows what duragesics are. I sure hope Endo makes them so they are water soluble.
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