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I've taken flexeril off and on for years now. After two car accidents in the last six months (not my fault), I have back pain every day. When the pain is caused by spasms, flexeril helps more and longer than hydro. My doctor is so stingy with hydro, it pisses me off. When my back just hurts so bad and I have no hydro left, I usually take 1 flexeril, 2 soma, and a couple ibuprofen. If it's at night, I'll add 1mg of ativan so I can get to sleep. I tried baclofen and that didn't help at all. I tried skelexen and it didn't do squat. Different people react differently, I guess.