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It is strange to me why we all have different experiences with different brands.
In my opinion, it is just reaction to the fillers, not the APAP or Hydro.... Different manufacturers use different dyes, starches, etc..... Mallie's actually use a lactose-based filler which other Hydro/APAP manufacturers do not use. Most people who say they get very sick from Mallie's, you end up finding out that they are Lactose Intolerant (just as Meowsie stated above - she is lactose intolerant and has bad reactions to the Mallie) - If you look at the 'inactive ingredients' on different Hydro/APAP combo's, they actually vary quite a bit. Also some people have bad reactions to certain starches (allergic reactions), etc..... I know a guy that can barely take ANY medicines (not just pain medicines) because he has some weird rare allergy to a starch that is used to bind together MOST medications on the market... I forget what it is called. His condition is rare, but it is very odd. He breaks out in a rash and hives with about 80% of the medications on the market. But, like I said - his is a rare case, a very rare allergic condition. But I think it is mostly attributed to variation of fillers, to summarize.