Knighthawk - I got that feeling of euphoria from the Imitrex injection - but not from the pill. However, it wasn't a really pleasant euphoria - it was kind of shaky and after a little while I would need to take a nap. Another migraine med that does that to me is Midrin (not motrin). If I take just one - I'm fine - if I take 2 I get a weird 'buzzy' feeling and also feel very warm and flushed. However, both meds work if I catch the migraine at the very start of it. I'd rather feel the effects I described than get the headache!