Agree with your assessment of Effexor XR and Wellbutrin SR in combo, SonicMan. I find myself breaking into spontaneous laughter in the grocery store... long way from Anhedonia. One minor correction, neither are SSRI's. Effexor is an SNRI and also a mild dopamine re-uptake inhibitor. Wellbutrin doesn't seem to fall into any current category. From reading it's prescribing info (the datasheet for the doctor) they don't seem to think it's a re-uptake inhibitor, but has some other dopaminergic and noradrenergic mechanisms. I only make this point, because I think SSRI's are nearly worthless, especially compared to these two bombers.
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"War on ...." is the wrong metaphor!