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Lemme quickly explain how NAC works, that might answer some questions:
Acetaminophen has a toxic metabolite, NAPQI. When you exceed the dosage of acetaminophen that your liver can handle (and this varies among people, it's determined by a variety of conditions), the extra acetaminophen has to be metabolized by another liver enzyme, and this causes the production of NAPQI. Glutathione is an antioxidant that binds to NAPQI so it doesn't screw up your liver. But if there is too much NAPQI, the glutathione cannot bind to all of it. When you don't have enough glutathione to cover all the NAPQI, the NAPQI will start killing liver cells.
NAC has several functions. It can take the place of glutathione to bind to NAPQI, and as a precursor to glutathione, it also increases the production and effectiveness of your own glutathione.
If you regularly take large amounts of APAP, your ability to destory NAPQI is going to be impaired. This is why, if you're not doing cold-water-extractions (which you're not allowed to talk about on this board), you should be on some kind of liver supplement.
kittykatbone: NAC wouldn't affect how well the lorcets work in your system. It only comes in to play when you are taking too much APAP, and that point you are beyond a therapeutic dosage of APAP anyway. So I would suggest taking it, it won't affect your quality of pain relief.
legan: Glutathione does a LOT of other things in the body besides deal with excess APAP. Were you taking it for another reason initially? It will help manage APAP toxicity, but NAC is more effective if you have to pick one.
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Re: How much is too much??? (Yawkaw3)
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