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I think it has more to do with each persons ability to convert codeine into morphine in their body. Codeine is converted to morphine in the liver by the CYP2D6 enzyme (about 10% is actually converted). About 6-10% of the population have poorly functional CYP2D6 enzymes, and so therefor do not get as much benefit from codeine. Some people have better functioning CYP2D6 enzymes, and get more codeine converted to morphine in their bodies, and so might get better pain management than with Hydro.
I guess I just wanted to act like I'm smart today
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Re: Tylenol 4 or Hydrocodone
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