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Meds, Medical Conditions, and Treatment >> Meds, Medical Conditions, and Treatment

WickedNoah
Member


Reged: 10/02/04
Posts: 122
Re: Opiate Treatment of Refractory Depression
      10/30/04 05:31 AM

Quote:

Quote:

naloxone is a full opiate ANTAGONIST. however it is not active orally.




Sorry, I meant to write antagonist and mistakenly wrote agonist.




It sure is a full antagonist, but at very, very low doses, the kinetics of binding at receptors, thus causing grouping of receptors (which activates them), and the amount of time that the part of naloxone that looks a lot like morphine (i.e. the part that activates the receptor) spends on the receptor, vs. the part of the molecule that keeps the receptor from being activated... well, I've lost everyone, but at very small doses naloxone is an agonist. It's arcane knowledge, but it's being exploited by Big Pharma at the moment.

Noah

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Entire topic
Subject Posted by Posted on
* Opiate Treatment of Refractory Depression Deimus 10/27/04 11:40 PM
. * * Re: Opiate Treatment of Refractory Depression toe   10/30/04 07:12 AM
. * * Re: Opiate Treatment of Refractory Depression tone   10/30/04 10:28 PM
. * * Re: Opiate Treatment of Refractory Depression toe   11/02/04 06:03 AM
. * * Re: Opiate Treatment of Refractory Depression Deimus   11/01/04 09:02 AM
. * * Re: Opiate Treatment of Refractory Depression tone   10/30/04 03:48 AM
. * * Re: Opiate Treatment of Refractory Depression AngelWolf13   10/28/04 03:15 AM
. * * Re: Opiate Treatment of Refractory Depression tone   10/30/04 03:42 AM
. * * Re: Opiate Treatment of Refractory Depression WickedNoah   10/30/04 05:03 AM
. * * Re: Opiate Treatment of Refractory Depression Deimus   10/29/04 12:32 PM
. * * Re: Opiate Treatment of Refractory Depression efffbeee   10/29/04 05:20 PM
. * * Re: Opiate Treatment of Refractory Depression Deimus   10/30/04 05:12 AM
. * * Re: Opiate Treatment of Refractory Depression WickedNoah   10/30/04 05:31 AM
. * * Re: Opiate Treatment of Refractory Depression Harry   10/30/04 07:14 AM
. * * Re: Opiate Treatment of Refractory Depression *DELETED* prettyday   10/28/04 04:43 PM
. * * Re: Opiate Treatment of Refractory Depression astrophel2   10/28/04 04:47 PM
. * * Re: Opiate Treatment of Refractory Depression jbnugget   10/28/04 08:13 PM
. * * Re: Opiate Treatment of Refractory Depression WickedNoah   10/28/04 08:52 PM
. * * Re: Opiate Treatment of Refractory Depression Deimus   10/27/04 11:44 PM
. * * Re: Opiate Treatment of Refractory Depression Deimus   10/27/04 11:42 PM

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