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ok, quick question. does buprenorphine(temgesic) in itself act as an opioid antagonist? or is it the addition of another substance (naloxone)as such that makes it that way (suboxone)? i have been wondering that for a while. i apologize if that has been answered on your post, but as i can't sit in front of my computer long enough to digest all of that, i thought i'd ask. plus, my adhd doesn't help.

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According to what I've read buprenorphine by itself does demonstrate a narcotic antagonist activity. The naloxone does too, of course, but the difference between the buprenorphine and the naloxone is that buprenorphine is a partial agonist opiate while naloxone is a full narcotic agonist.

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