Whosoever is spared personal pain must feel himself called to help in diminishing the pain of others.
Dr Albert Schweitzer



Meds, Medical Conditions, and Treatment >> Meds, Medical Conditions, and Treatment

WickedNoah
Member


Reged: 10/02/04
Posts: 122
Re: Interesting Link: Dihydrocodeine, Biotran
      10/12/04 09:36 AM

Thanks for so much great info! Where did you come from, Virola? We need more posts from you!

I come from a chemistry perspective and feel like adding something for the other chemistry geeks - first, it's analgesic potency in basically animal assays is only 1.15 that of codeine. Second, dihydrocodeine basically IS codeine. It's the codeine molecule with a single bond between two carbons, whereas codeine has a double bond. The term "dihydro" comes from this - carbons need 4 bonds to be happy, and in the codeine molecule the double bond helps to do this. But with the single bond, the 2 carbons need to bind hydrogens to fill the 4-bond rule, hence "dihydro".

Like Virola said, it's not as special as people may think. In the 1930s, for reasons still not clear but maybe having to do with the war, the Brits went with DHC and we went with hydrocodone for stronger pain relief than could be had over the counter. Hydrocodone is of course stronger, and I don't know if they just give patients a ton of DHC in Britain or what, but they still don't use hydrocodone very much. Weird, huh?

Noah

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Entire topic
Subject Posted by Posted on
* Interesting Link: Dihydrocodeine, Biotran virola 10/09/04 03:35 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran TheNewGuy   10/10/04 09:26 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran dws1   10/10/04 09:37 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran CARLITOS_WAY   10/10/04 09:41 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran dws1   10/10/04 09:53 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran 4U2NV   10/10/04 10:16 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran dws1   10/10/04 10:30 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran AngelWolf13   10/10/04 10:04 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran CARLITOS_WAY   10/10/04 10:40 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran dws1   10/10/04 10:47 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran virola   10/12/04 03:32 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran WickedNoah   10/12/04 09:36 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran stevesmith   10/12/04 09:43 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran WickedNoah   10/12/04 09:51 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran virola   10/13/04 03:49 AM
. * * Re: Interesting Link: Dihydrocodeine, Biotran dws1   10/10/04 10:13 PM
. * * Re: Interesting Link: Dihydrocodeine, Biotran AngelWolf13   10/09/04 11:25 AM

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