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worthless and dangerous non-opiate "pain killer".
below are quotes from tramadol's offical monograph
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at least two complementary mechanisms appear applicable; binding to µ-opioid receptors and inhibition of reuptake of norepinephrine and serotonin. Ultram opioid activity derives from low affinity binding of the parent compound to µ-opioid receptors and higher affinity binding of the M1 metabolite. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in µ-opioid binding.
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Although tramadol can produce drug dependence of the µ-opioid type (like codeine or dextropropoxyphene) and potentially may be abused, there has been little evidence of abuse in foreign clinical experience. In clinical trials, tramadol produced effects similar to an opioid, and at supratherapeutic doses was recognized as an opioid in subjective/behavioral studies. Tolerance development has been reported to be relatively mild and withdrawal when present, is not considered to be as severe as that produced by other opioids. Part of tramadol's activity and some extension of the duration of µ-opioid activity. Delayed µ-opioid activity is believed to reduce a drug's abuse liability.
so, although you can say its a non-opiate chemically because it doesnt have the morphine-like structure, you couldnt say its a non-opioid in terms of its mechanism of action. you can also say that methadone and fentanyl are non-opiates chemical because they are nothing like the morphine structure as well.
they said "Delayed µ-opioid activity is believed to reduce a drug's abuse liability" -- that is so true because i notice its opioid feel is so delayed and drawn out, almost like its time released without being in a special time release pill. one cannot take tramadol and get any rush from it, the onset is so gradual and the effects are so drawn out...but thats the way i like it, it kills mental and physical pain longer and smoother
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Most effective pain relief available from IOP's?
Horace
09/27/04 04:03 AM
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10/03/04 01:59 AM
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10/06/04 11:37 PM
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09/27/04 10:49 AM
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