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I know that fioricet has caffeine in it, but it doesn't make me jittery at all. In fact, when I took one I couldn't function at all. It totally kicked my butt. I couldn't see straight and it was impossible to stay awake after about an hour. I thought that I might have a tolerance to it since I regularly take hydro, but it didn't work out that way. They must be quite different chemically from hydro. They did make me rather nauseous though.