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While the bupe equivalency for pain may seem high, it does not produce the euphoric"everthing will be ok" feeling brought on by the short term full agonists. This is because its mixed agonist/atagonist activity produces a ceiling effect. Also, at least in my case, it has induced horrible migraine headaches. I for one am happy to be getting off it. Anyone been through bupe withdrawl? When will it begin? What is the severity like? I've been on a taper schedule. Any advice how long does the drug block your receptors?
Uh, the half-life is about 2.5 days, so in about 10 days you should only have about 5% of the drug left in your body.
You're the first poster who's actually mentioned negative effects of bupe! I'm sorry it induced migraines; the way it's been talked about (partly due to the mystery of it because high doses are hard to get), it's a miracle drug.
Since the half-life is so long, your body tapers off extremely gradually all by itself and the w/d is supposed to be very minimal. You don't need to regulate your dosage or anything; just taper down to a reasonable amount and then stop. It will decrease a few percent every day until it's gone. Gosh, I'm so sorry about the migraines, though - do other opioids do that to you, too? Anyone else have experience?
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