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Sigh - we're talking about benzos here, not Tagamet. Here's what you said:
"thats an EZ question. no need for long replies. the answer very simply is tagamet. tagamet inhibits CYP2D6 and incrases blood levels and extends the already enormus half-life of valium. i recommend against it and grapfruit juice. to potentiate, raise your dose, that way you raise the strenth without raising the half life or disabling detox mechanisms."
Tagamet's effects on benzo metabolism are on the 3A4 enzyme; 2D6 has nothing to do with it. Grapefruit juice also inhibits CYP3A4, so it's part of the "answer", too. Anything else you want to add? If you're thinking preemptively, Tagamet also inhibits CYP1A2, a minor pathway for acetominophen metabolism, and CYP2C19, a minor pathway for Valium metabolism.
Try PubMed for more info than a product sheet. And not just the abstracts, either.
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Re: potentiators for Valium?
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