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I took the Norco 10/325's for a while and found that they really didn't do much of anything. I thought it was a tolerance thing, but on a hunch I decided to go back to the 7.5/500's I was on prior. Well, that did the trick. Here I thought I was "upgrading" with going to the 10/325's and they were a complete bust for me but the 7.5/500's really did work better right away. I've since gone onto the 10/500's and they also work well. For me, I guess the extra tylenol actually makes the difference.