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I was prescribed Doxepin 25mg last month for a very serious case of the shingles.I believe it was the 2nd or 3rd day that this medication reached noticeable strength. It definately helped in relieving my stress and totally 86ing my depression.Well, i hope this med works for you,if i have time (i'm currently at work)i'll do some in-depth research on this med and report back with my findings.