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When people take too much acetaminophen, they can suffer a sometimes fatal liver injury. Acetaminophen causes nearly 50 percent of all acute liver failure, four times that caused by all prescription drugs combined. Acetaminophen overdose is the leading cause for calls to poison control centers (more than 100,000 per year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations and about 450 deaths each year. Is such suffering and death really acceptable for an over-the-counter pain reliever?

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Almost 500 deaths attributable annually to the misuse of acetaminophen may not seem like many, especially considering that about one billion tablets are sold each year. But they are not acceptable side effects.

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