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being on the naltrexone would upregulate my mu receptors much like being on opioids downregulates them, so would this reset my sensitivity to opioids and make it almost like i never took them before? in otherwords, would this treat my tolerance more so than just taking a break from opioids without using naltrexone to upregulate?
I disagree. Tolerance to opiates stems from the additional growth of receptors. For example, an opiate-naive person has (for example's sake only...) 100 mu receptors. The same person gets oxycodone for, say, 6 months worth of treatment...now that person has 200 receptors and it takes twice as much of the drug to be effective. The opposite is also true. If that same person with 200 receptors goes on a taper schedule for 3 months and is off opiates entirely, within that 6 month period, the extra receptors die off and the person's tolerance goes way down.
So, using an antagonist won't actually kill off the extra receptors. It will only displace the opiates for the duration of it's action (which is generally shorter than the action of most opiates.) Only time and abstinence will reduce the number of receptors. And a week or two's "holiday" doesn't really make a huge difference in this reduction of receptors.
This is how my anesthesiologist explained it to me. I will have to look and see if I can provide any references to this.
-------------------- Never underestimate the predictability of stupidity.
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Question about Opioids....
tone
02/17/04 09:19 PM
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night_shade
02/18/04 09:35 AM
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tone
02/18/04 01:48 PM
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karmapolice
02/17/04 10:31 PM
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Trampy
02/17/04 10:58 PM
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tone
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Trampy
02/18/04 03:11 PM
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tone
02/18/04 06:38 PM
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tone
02/17/04 10:54 PM
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