DrugBuyers.Com: Is Buprenorphine the "miracle" for opiate withdrl?

Bupe will work for pain relief, you can take other opites with it, however depending on the individual and how much bupe you take it can effect the ability of other opiates to work. There is no reason to take another opiate with bupe, at least as far as I know. (the only exeption to that might be if one were in extreme withdrawal and did not have enough of a single opiate to stop or slow down the withdrawal)

Bupe is an agonist/antagonist that binds with extreme voracity to the opiate receptors. For people who are not used to taking opiates bupe will wallop them pretty hard. The higher your tolerence to opiates the less potent it will be. Counter-intuitively, after you take a given amount, again depending on the person and their tolerance it will precipitate withdrawal. If you have a high tolerance to opiates and take a high dose it can preciptate withdrawal. If you have a medium tolerance for opiates and you take a moderate amount you could feel it pretty strongly. But if you have a medium tolerance and take too much it will precipitate withdrawal. If you have a high tolerence for opiates and are in withdrawal and take the appropriate amount you will experience serious relief from withdrawal, if you take too much it can make the withdrawal worse.

At the right level it acts as a blocker, like naltrexone.However, I think, but am not sure, that it binds much more tightly to the receptors than naltrexone. For example: If you are taking naltrexone and are hit by a car and rushed to the ER they can give you enough opiates to push the naltrexone out of the way of the recepotors thus giving you pain relief. If you go into OD they administer a shorter acting antagonist to push the opiates out of the way and bring you out of OD.

I am not sure if they can do this with bupe. Nor I am sure how the loop works. At what point does one precpitate withdrawal and can you chase it? If you are in withdrawal from taking bupe, will taking more bupe give you relief? Or cause further withdrawal. Or will it cause a harsher withdrawal? And if that is the case how long do you have to wait before the bupe level drops and starts to act like an agonist and relives the withdrawal?

I asked a Dr the above questions, but he did not have the anwser. I think I asked more questions than anwsered, but am interested in the anwsers. Thank you, Z