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night_shade
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Reged: 08/26/03
Posts: 907
Loc: The State of Hockey
Re: liver failure
      01/27/04 11:50 AM

I'm certainly not an expert on hepatotoxicity, but my semi-educated opinion would be acetaminophen overdose/toxicity rather than hydrocodone toxicity of the liver in the case you specified.

Hydrocodone IS broken down in the liver into its metabolites, but a person would die from respiratory depression from hydrocodone's metabolites long before anything could accumulate in the liver in quantities sufficient to cause liver failure.

If someone is using 30-40 regular 5/500 Vicodins every day--and in order to do so for any period of time without causing death by opiate overdose, that person would have developed a tolerance to the hydrocodone--that would be 15,000 mgs (15grams) to 20,000 mgs of acetaminophen per day for a long period of time. This is DEFINITELY enough to damage and eventually cause complete failure of the liver.

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Subject Posted by Posted on
* liver failure snakey 01/27/04 11:43 AM
. * * Re: liver failure yawkaw3   01/27/04 10:59 PM
. * * Re: liver failure Dasani   01/28/04 05:44 AM
. * * Re: liver failure BlackCat   01/28/04 07:45 AM
. * * Re: liver failure Dasani   01/28/04 07:52 AM
. * * Re: liver failure lemongrass   01/28/04 12:38 PM
. * * Re: liver failure gottadoit   01/28/04 06:34 PM
. * * Re: liver failure yawkaw3   01/28/04 10:05 PM
. * * Re: liver failure-MOST IMPORTANT SYMPTOMS!! sassyg   02/14/04 07:45 AM
. * * Re: liver failure-MOST IMPORTANT SYMPTOMS!! Tred   02/16/04 06:07 PM
. * * Re: liver failure snakey   01/29/04 03:50 AM
. * * Re: liver failure prettyday   01/28/04 07:04 PM
. * * Re: liver failure turcica   02/16/04 07:10 PM
. * * Re: liver failure Caveman6666   02/17/04 06:34 AM
. * * Re: liver failure snakey   01/28/04 05:24 AM
. * * Re: liver failure D2003   01/27/04 01:57 PM
. * * Re: liver failure joyous   02/13/04 11:25 PM
. * * Re: liver failure pickles   01/27/04 12:38 PM
. * * Re: liver failure night_shade   01/27/04 11:50 AM
. * * Re: liver failure snakey   01/27/04 12:02 PM

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