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I started getting debilitating migraines as a teenie bopper. My doc back then ALWAYS gave me Demerol in combination with an anti-emetic. Demerol worked great until it wore off, and stopped the vomiting, but my headaches almost always outlasted the Demerol injections. My neurologist tried Inderal (sp?) but that made me feel like I wanted to kill myself (literally) and Midrin was OK IF I got it in my system early enough (at first sign of the aura) but Imitrex made me have such serious muscle spasms that I was hospitalized for it. I also tried Fioricet, but it was only slightly effective for my headaches. I tried Ergotamine/Caffeine too...had very strange side effects, but was also somewhat effective.
Even with all the different drugs I tried over the years (and not all are listed here) the most effective analgesic is Demerol or Stadol with Vistaril in combination with EXCEDRIN MIGRAINE. Believe it or not, the Excedrin really helps and is, of course OTC. Problem is, few ER's give narcotics for migraines any longer. Most docs won't prescribe them regularly, either. If you suffer very frequent headaches, a neurology appointment is a must.
Good luck and best wishes!
-------------------- Never underestimate the predictability of stupidity.