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Zanaflex is a centrally acting alpha2-adrenergic agonist. Tizanidine HCl is a white to off-white fine crystalline powder, odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol; solubility in water decreases as the pH increases. Its chemical name is 5-chloro-4-(2-imidazolin-2-ylamino)-2, 1,3-benzothiodiazole hydrochloride. Tizanidine's molecular formula is C9H8ClN5S·HCl, its molecular weight is 290.2.
Zanaflex is supplied as 4 mg tablets for oral administration. Zanaflex tablets are composed of the active ingredient tizanidine hydrochloride (4.576 mg equivalent to 4 mg tizanidine base), and the inactive ingredients, silicon dioxide colloidal, stearic acid, microcrystalline cellulose and anhydrous lactose.
INDICATIONS AND USAGE
Tizanidine is a short-acting drug for the acute and intermittent management of increased muscle tone associated with spasticity. The reduction of muscle tone that follows the oral administration of a single dose of tizanidine has its peak effect 1 to 2 hours after dosing, and the effect dissipates between 3 to 6 hours. Use must therefore be individualized, directed to those activities and times when relief of spasticity is most important and titrated to avoid intolerance. Evidence demonstrating the effectiveness of tizanidine is derived from a single dose study and from a seven week multiple dose study conducted in patients with multiple sclerosis and spinal cord injury, respectively.
PATIENT INFORMATION
Tizanidine is used for treatment of increased muscle tone associated with spasticity.
Inform your physician if you are pregnant or nursing.
Inform your physician if you have kidney disease or liver impairment.
May cause significant hypotension; Do not rapidly arise from a prone position.
Inform your physician if you are taking concurrent antihypertensive medication.
May cause sedation; use caution while driving or operating hazardous machinery.
Hallucinations have been reported; be aware of this possibility.
Inform your physician if you are taking any other medications, including over-the-counter drugs (e.g. acetaminophen).
Do not drink alcohol with tizanidine.
Oral contraceptives can prolong the effect of tizanidine.
May cause dry mouth, sleepiness, slowed heart rate, weakness, and dizziness.