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Klonopin, a benzodiazepine, is available as scored tablets with a K-shaped perforation containing 0.5 mg, 1 mg or 2 mg clonazepam, and unscored tablets with a K-shaped perforation containing 1 mg or 2 mg of clonazepam. Each tablet also contains lactose, magnesium stearate, microcrystalline cellulose and corn starch, with the following colorants: 0.5 mg: FD&C yellow no. 6 lake; 1 mg: FD&C blue no. 1 lake and FD&C blue No. 2 lake.
Chemically, clonazepam is 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has a molecular weight of 315.72. The molecular formula is C15H10ClN3O3.
Seizure Disorders: Clonazepam is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, clonazepam may be useful.
In some studies, up to 30% of patients have shown a loss of anticonvulsant activity, often within 3 months of administration. In some cases, dosage adjustment may reestablish efficacy.
DOSAGE AND ADMINISTRATION
Adults: The initial dose for adults should not exceed 1.5 mg/day divided into 3 doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg.
The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding clonazepam to an existing anticonvulsant regimen.
Pediatric Patients: Clonazepam is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in 2 or 3 divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into 3 equal doses. If doses are not equally divided, the largest dose should be given before retiring.
Clonazepam is used for the treatment of seizures. Notify your physician if you are pregnant or nursing. This medication may cause dizziness, drowsiness, or blurred vision; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking clonazepam. Do not change the dose or stop taking clonazepam without talking with your physician. This medication may be habit forming. Seizures or withdrawal symptoms may occur after you stop taking it. This medication should be taken with meals to avoid stomach upset.
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I have been wondering something about klonopin and benzos in general and was wondering if anyone could answer this .
I worry about tolerance/dependence so i use 1.5 mg every 3 days ( on the 3rd day ) , Is it worth doing this to try and avoid dependence or does dependence come from Cumulative usage rather then regularity or are both factors involved ?
both factors are involved and at that rate, you will definitely get tolerant/dependent; especially considering the long half-life of clonazepam (klonopin). 1.5mg is also a pretty high dose, especially for a non-tolerant person.
The half life of Klonopin is 16-20 hours. If the poster is only taking Klonopin every 3rd day, physical dependence is not a concern. Psychological dependence may a different matter since that is an individual thing.
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