Melody
Moderator
Reged: 03/20/03
Posts: 674
Loc: DrugBuyers.Com
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Codeine is an alkaloid obtained from opium or prepared from morphine by methylation and occurs as white crystals. Codeine effloresces slowly in dry air and is effected by light. The chemical name of codeine phosphate is 7,8-Didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol phosphate (1:1)(salt) hemihydrate and has the empirical formula of C18H21NO3·H3PO4·1/2H20. Its molecular weight is 406.4.
Each soluble tablet contains 30 mg (0.074 mmol) or 60 mg (0.15 mmol) of codeine phosphate. These tablets also contain lactose and sucrose.
Soluble tablets of codeine phosphate are freely soluble in water. They are intended for the preparation of solutions for parenteral administration. These tablets are not sterile. Codeine phosphate is an analgesic.
INDICATIONS
Codeine phosphate is an analgesic indicated for the relief of mild to moderate pain.
DOSAGE AND ADMINISTRATION
For Analgesia: Dosage should be adjusted according to the severity of the pain and the response of the patient.
Adults: 15 to 60 mg every 4 to 6 hours (usual adult dose, 30 mg).
Children: 1 Year of Age and Older - 0.5 mg/kg of b.d. weight or 15 mg/m2 of b.d. surface every 4 to 6 hours.
Soluble tablets codeine phosphate are administered subcutaneously or intramuscularly.
Solutions for injection should be prepared with sterile water and filtered through a 0.22 membrane filter.
Note: Do not use the solution if it is more than slightly discolored or contains a precipitate.
PATIENT INFORMATION
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
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nikkicat
Newbie
Reged: 11/30/04
Posts: 38
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Whats the difference between codeine phosphate and codeine sulphate?
thanks!
nikki
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rockystuart
Enthusiast
Reged: 03/11/04
Posts: 232
Loc: San Fran Bay Area, Calif
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There is not too much difference between the phosphate and sulphate. The phospate will be slightly weaker on a mg to mg basis because the base molicule weighs more than the sulpher. It's strange but morphine is usually done as a sulphate and codeine is done as a PHOSPATE.
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anxious100
Member
Reged: 11/24/04
Posts: 133
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I find this to be the best asthma medication there is, I know it's not commonly found on Western markets, but having purchased Codine Sulphate in France and taken it at times when I have asthma issues (which is very often), it's been a great help to me.
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nikkicat
Newbie
Reged: 11/30/04
Posts: 38
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How much tynenol doesezch tylenol 4 have in it? It says the 60 mg of codeine but does not indicate amount of codeine.I ussually take norco 10/325 but has to switch to the tynenol 4 for a bit to decrease tolerance to the hydro codone. It is not as strong but it keeps the pain at bay just concerned about the amount of tylenol. Anybody know? I even researched it and could not find the answer!
Thanks!
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CARLITOS_WAY
Enthusiast
Reged: 06/27/04
Posts: 274
Loc: WASHINGTON, USA
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Quote:
How much tynenol doesezch tylenol 4 have in it? It says the 60 mg of codeine but does not indicate amount of codeine.I ussually take norco 10/325 but has to switch to the tynenol 4 for a bit to decrease tolerance to the hydro codone. It is not as strong but it keeps the pain at bay just concerned about the amount of tylenol. Anybody know? I even researched it and could not find the answer!
Thanks!
300 mg of Tylenol (APAP)
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JethroBodine
Enthusiast
Reged: 06/20/03
Posts: 211
Loc: Ozark Mountains
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Codeine Phosphate (C18 H21 NO3). H3PO4 . 1 1/2 H2O mw424
Codeine Sulfate (C18 H21 NO3)2 . H2SO4 . 5H2O mw786
per molecule of codeine base, the phosphate is 8% heavier. Therefore in a mass comparison, the sulfate is a little stronger. If you can accurately cut your pills into 12 parts, you could make up for it.
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Lablady2
Old Hand
Reged: 05/05/04
Posts: 468
Loc: New York City
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Chemistry major???? I rarely see someone post re molecular weights and chemical composition on this board - and you live in the Ozarks???? Just teasing - couldn't resist:) I really enjoy your posts - you are a very knowledgable person!
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