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Meds, Medical Conditions, and Treatment >> Meds, Medical Conditions, and Treatment

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jazee
Journeyman


Reged: 09/16/04
Posts: 53
Tramadol - Long Term Safety?
      #209469 - 12/22/04 09:26 AM

I've been using Tramadol ocassionally as an alternative to using the Canadian Over The Counter Tylenol+Codeine+Caffeine tablets for occassionaly moderate pain. I've been really happy with this drug. It's a very effective pain killer but doesn't feel addicting as the onset is very gradual. I've read recently about the anti-depressent effects this drug also has. I would admit that I now find myself reaching for this drug more often instead of even just the plain Tylenol for mild-moderate pain. However, I've never taken more than 50mg in a day, and I'd say I've averaged over the past two months taking this drug 2 days per week, maybe 3 days per week at most.

I'm curious about two things, I'd assume taking 50mg a day only 2-3 days a week doesn't really pose a significant addiction/dependence potential. It seems the horror stories for withdrawl from this drug come from people either taking at least 50mg every day for an extended period, or those of have taken large dosages for a short period most of the time 150mg or more for several days.

The thing I am worried about though is the long term effects of this drug regarding its anti-depressent properties. I didn't choose this drug for those properties but am wondering if maybe I am unintentionally becoming slightly addicted to it even in these low, inconsistent dosages? I don't think so but I'd be curious to hear other people's experience in similar situations. It seems that 50mg of this stuff would have anti-depressent properties equivalent to very very low doses of drugs that are designed primarily of anti-depressents right?

Also, I've scoured the Internet and could not find any BAD research results on the use of this drug. It seems the scientists/doctors having nothing but good things to say about this drug especiall compared to the other pain killers. The only bad mark against it is the potential for seizures at higher dosages (I think 150mg and up) but this seems like sort of a built in safety factor.

Now just the other day, they say Naproxen (Aleve) can be bad for the heart so now there's one less choice for OTC pain killers out there.

Does anyone know of any information that indicates there can be siginificant potential for negative long-term effects of low dosages of Tramadol? Because I don't see any reason to use Tylenol anymore for occasional pain if I've got this stuff around. I know I still need to use Ibuprofen if I want anti-inflamatory effects.


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adept
Stranger


Reged: 12/19/04
Posts: 1
Re: Tramadol - Long Term Safety? [Re: jazee]
      #209591 - 12/22/04 05:21 PM

I have been using tramadol (Ulram)for about 2 years - 50mg 1/2 hour before bed. Periodically, I intentionally skip a day or 2 to see if I have any dependency other than the pain I take it for. So far, I have noticed no addiction. A doctor had gotten me hooked on Oxycottin for about 2 years, so I know what addiction is like - it took me 3 months to get over that.

I have a question, though. I have a very specific chronic pain in my right back as a result of an accident. I searched for a long time for a moderate pain reliever that would help. Tramadol seems to work very specifically on this problem. BUT, it doesn't seem to have much affect on my arthritis and other pain.

I'm not complaining ... just wondering why Tramadol would be
site specific in it's effect.

Thanks,


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jazee
Journeyman


Reged: 09/16/04
Posts: 53
Re: Tramadol - Long Term Safety? [Re: adept]
      #210015 - 12/24/04 04:06 PM

Your problem is that Tramadol has only minor anti-inflamatory effects. I just got an e-mail from my pharmicists about this regarding my muscle pains. They recommended supplementing the Tramadol with Ibuprofen. I'm sure that will help with your arthritis. Stay away from the Naproxen though. They just found out, long-term use if bad for the heart. A lot of people take it for Arthritis.

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tone
Veteran


Reged: 06/29/03
Posts: 554
Loc: Chicago
Re: Tramadol - Long Term Safety? [Re: jazee]
      #210076 - 12/24/04 11:21 PM

it should be studied weather or not tramadol causes any significant serotonin depletion over the long term. some studies showed that tramadol not only inhibited reuptake of 5-HT, but also forced some release.

other than that possibility, and it is only a hypothetical possibility, its rather benign in the long term


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