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Piracetam is reported to be an intelligence booster and CNS stimulant with no known toxicity or addictive properties.
The subjective effect described by some people is that piracetam, "wakes up your brain." Its effects and safety are so impressive that piracetam prompted the creation of a new pharmaceutical category called nootropics. Since the invention of piracetam by UCB Laboratories in Belgium, other pharmaceutical companies have been scrambling to develop their own nootropics. Others include: vinpocetine, aniracetam, pramiracetam, and oxiracetam. As yet, there is no nootropic compound that FDA approves for sale in the US, but there is plenty of motivation on the part of pharmaceutical companies to get that approval.

Piracetam is very similar in molecular structure to the amino acid pyroglutamate (see Pyroglutamate). Piracetam and pyroglutamate have the same "base" chemical structure, the 2-oxo-pyrrolidine, but they differ by the side chain. Pyroglutamate is 2-oxo-pyrrolidine carboxylic acid, and piracetam is 2-oxo-pyrrolidine acetamide. Piracetam enhances cognition under conditions of hypoxia (too little oxygen), and also enhances memory and some kinds of learning in normal humans. Outside of the US, piracetam is used to treat alcoholism, stroke, vertigo, senile dementia, sickle cell anemia, dyslexia, and numerous other health problems. The effect of piracetam can be increased if taken with DMAE, centrophenoxine, choline, or Hydergine. When choline and piracetam are taken together there is a synergistic effect that causes a greater improvement in memory than the sum of each when taken alone. It may be that piracetam causes acetylcholine to be used up more quickly and that the choline helps to replace this important neurotransmitter. Studies suggest that piracetam might increase the number of cholinergic receptors in the brain. Older mice were given piracetam for two
weeks and then the density of muscarinic cholinergic receptors in their frontal cortexes was measured. The researchers found that these older mice had 30-40% higher density of these receptors than before. Piracetam, unlike many other drugs, appears to have a regenerative effect on
the nervous system. Combination of Hydergine and Piracetam potentiate each other by 5 times. This highlights the importance of adjusting the dosage when multiple substances are taken because, some of these substances will cause paradoxical effects when excessive amounts are taken. Although piracetam is a derivative of GABA (gamma amino butyric acid, a neurotransmitter), there is no evidence that piracetam works through the GABA-ergic system. Some research even suggests GABA may even inhibit memory
and learning.

Piracetam is supplied in 400mg or 800mg capsules or tablets. The usual dose is 2400 to 4800 mg per day in three divided doses. Some literature recommends that the first two days a high "attack" dose should be taken. Often when people first take piracetam they do not notice any effect at all until they take a high dose (approximately 4000 to 8000mg). Thereafter, they may notice that a lower dosage is sufficient. Piracetam takes effect within 30 to 60 minutes.

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