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WickedNoah
Member
Reged: 10/02/04
Posts: 122
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Quote:
The only lipid-soluble opioid i know of is methadone. Are there others?
This is coming really late in the thread, but Fentanyl is lipophilic. The Duragesic patch works by having it seep into your skin, getting past the lipid bilayers of the skin cells, all seven or so layers of them, and into your bloodstream.
You know there's a drug called alfentanil? It's like opiate crack! The high is instant, 800 times stronger than morphine and 8 times as strong as Fentanyl. You can't separate pain relief from the euphoria, so I'm not breaking any laws by mentioning the high, I think. It's broken up by esterases within 10 minutes, and it's effectively inactive then. Crazy! Its trade name is Alfenta.
There's a related one, called Ultiva, that is metabolized so fast it comes in mg doses, but it's actually stronger than alfentanil, it's just cut up so quickly you have to use a ton of it. These two are part of a class of new opioids that are in and out tremendously fast, and for use in clinical settings, I guess. But who needs hardcore pain relief for only 5 minutes? Oh well, science moves ahead and society follows.
Also, I can't help but mention, but DXM, dextromethorphan, is the stereoisomer of levorphanol? For those of you who don't know these terms, stereoisomer means the mirror image, so the molecule is the same with bonds, ions, etc., but the bonds stick out in different directions in 3D space. The cool thing is that levorphanol is EXTREMELY strong, while DXM has very little binding to opiate receptors. Cool, huh? Just a little bar talk...
Noah
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JBRONCFAN
Member
Reged: 04/20/04
Posts: 124
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I also read on the other forum taking mass amounts of grapefruit juice has the same effect of tagament.
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WickedNoah
Member
Reged: 10/02/04
Posts: 122
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Quote:
I also read on the other forum taking mass amounts of grapefruit juice has the same effect of tagament.
It's "Tagamet", not "Tagament". If you spell it incorrectly, and almost everyone does, it doesn't come up when a person who is able to spell tries to do some research on it. It's gotten to be so prevalent that I had to say something. It's not personal, and it's not just you, but about 50% or more posters spell it "Tagement" and people miss out on a lot of info.
Grapefruit juice inhbits CYP3A4, and Tagamet does, too. But Tagamet also inhibits CYP2D6, and hydro gets turned into Dilaudid in smallish (10-15%) by CYP2D6. But hydro is made inactive by CYP3A4, so you have to weight the two against each other. I drink grapefruit juice.
Grapefruit juice from concentrate is better because the skin is used, which has CYP3A4 inhibiting proteins, while more fresh grapefruit juice does not.
I don't know about Ruby Red, but I wouldn't drink it.
Noah
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trixxie
Member
Reged: 05/23/03
Posts: 121
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Quote:
Quote:
I also read on the other forum taking mass amounts of grapefruit juice has the same effect of tagament.
I don't know about Ruby Red, but I wouldn't drink it.
Noah
Why not Ruby Red? I prefer that kind...and why condensed?
TIA
trixxie
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The truth shall set you free!
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