jandkwatts1
Stranger
Reged: 05/04/04
Posts: 9
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I took my first pill today and had extreme nausea. Does anyone else have bad nausea with this drug?
I'd rather be in pain than this nauseated. I felt like puking all day.
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Stardog
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Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
I took my first pill today and had extreme nausea. Does anyone else have bad nausea with this drug?
I'd rather be in pain than this nauseated. I felt like puking all day.
Taking Dramamine Daytime should help you out. The dosage depends on the individual, though - I get numb fingers when I take Dramamine or Benadryl or any other antihistamine, but you gotta weigh the pros and cons.
I guess I should mention, then, that taking ANY antihistamine should help; just try them and see which one works best. The list includes:
Axid
Pepcid AC
Tagamet
Benadryl (or anything with diphenhydramine in it)
Dramamine (day or night formulas)
Contac 24 (or anything with chlorpheniramine)
Claritin
Here's hoping that the first one you try is the best!
(Personal disclosure: I take Claritin every morning and Pepcid AC at night, and have often taken Dramamine. They all have worked for me.)
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dman22
Enthusiast
Reged: 05/01/04
Posts: 264
Loc: Everywhere
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For some reason, Lortab always made me sick big time. I didn't have that problem with Vicoden ES though. Wierd, but Yes - I've had that happen.
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CARLITOS_WAY
Enthusiast
Reged: 06/27/04
Posts: 204
Loc: WASHINGTON, USA
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Take a half pill next time. Some people feel very fine with 5mg, and nausea with 10mg.
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LuckyDee
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Reged: 02/05/02
Posts: 120
Loc: Georgia
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JandK, where did you receive these lortabs from. It seems in my experience that there are some forms of lortab 10/660's especially that made me nausous also and had no potentcy whatsoever in regard to my pain/ They are usually from the non-record OP's. Curious where the 650's came from? Lucky
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seaofyouth
Journeyman
Reged: 09/22/03
Posts: 77
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These are not antihistamines:
Axid
Pepcid AC
Tagamet
Tagamet(cimetidine) will actually greatly retard the breakdown of Codeine, hydrocodone, and some benzodiazepines.
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GreatDaneDad
Stranger
Reged: 02/28/04
Posts: 11
Loc: Virginia
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Hello,
I do not believe that it is the 10 Mg of the Hydro that is making you nausea, It is the 650 of the acetaminophen..(Sp?). You can always ask your doc for phenergan which is made for nausea or compazine they are made in table as well as suppository form and work very well as I have to use them for other reasons
GDD
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Those Of Us That Look Will Find What We Are Looking For.....
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Steve623
Banned: multiple board accounts. Disregard the feedback provided by this user.
Reged: 08/24/04
Posts: 89
Loc: NY, USA
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I agree! 10/325 do NOT make me nauseous, but 7.5/750 do.
There is more hydro in the 10's but less tylenol
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DonBarba
Enthusiast
Reged: 04/02/04
Posts: 260
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Quote:
I do not believe that it is the 10 Mg of the Hydro that is making you nausea,
Amazing as it seems to me, I've known plenty of people who can't tolerate any opiod, even a T2. They get dizzy and feel sick & nauseous (and if they're real nice, give me their pills  - just kidding!)
To quote rxlist
Quote:
The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients and some of these adverse reactions may be alleviated if the patient lies down.
I'm guessing that the original poster is taking Hydro for the FIRST time, and is not used to any opioid; in which case 10mg is possibly a high dose.
He should try taking 1/2 pill, after all, most Drs initially prescribe no more that 5mg for even some post-op pain.
Also, if one needs all sorts of work-arounds to tolerate any medication; maybe they should try something else. Don't remember if his medical condition was mentioned....
Edited by DonBarba (09/08/04 08:53 AM)
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Greycie
Old Hand
Reged: 07/08/03
Posts: 461
Loc: Pacific NorthWest
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Everybody will have a different reaction to different medication. For me, I get nauseated when I take any narcotic medication. The only thing that makes me feel alright is if I get plenty of fluids. I literally am constantly drinking water or some water type drink when I'm medicated or I'll get nauseous. Not saying this will help you, but you never know.
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"I may not agree with what you say, but I will defend to the death your right to say it." - Voltaire
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Stardog
Member
Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
These are not antihistamines:
Axid
Pepcid AC
Tagamet
Tagamet(cimetidine) will actually greatly retard the breakdown of Codeine, hydrocodone, and some benzodiazepines.
They sure are antihistamines; don't get out of your depth, Junior. And they do help with nausea associated with opioid use. Tagamet will inhibit the breakdown of some benzos, but nobody ever mentioned taking benzos in this thread. It is also true that it retards the breakdown of codeine and hydrocodone, but not by much. The pros will likely outweigh the cons.
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Stardog
Member
Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
Quote:
These are not antihistamines:
Axid
Pepcid AC
Tagamet
Tagamet(cimetidine) will actually greatly retard the breakdown of Codeine, hydrocodone, and some benzodiazepines.
They sure are antihistamines; don't get out of your depth, Junior. And they do help with nausea associated with opioid use. Tagamet will inhibit the breakdown of some benzos, but nobody ever mentioned taking benzos in this thread. It is also true that it retards the breakdown of codeine and hydrocodone, but not by much. The pros will likely outweigh the cons.
Oh, I can't help myself! Here's proof that you don't know what you're talking about:
(from rxlist.com)
1.The active ingredient in Pepcid is a histamine H2-receptor antagonist. Famotidine is N'-(aminosulfonyl)-3-[[[2- [(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide. The empirical formula of famotidine is C8H15N7O2S3 and its molecular weight is 337.43.
2.Nizatidine (Axid) is a histamine H2-receptor antagonist. Chemically, it is N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl] methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine.
3.Cimetidine HCl (Tagamet) is a histamine H2-receptor antagonist. Chemically it is guanidine, N''- cyano-N-methyl-N¢- [2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-monohydrochloride.
Tee hee!
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jandkwatts1
Stranger
Reged: 05/04/04
Posts: 9
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thanks stardog. i will try this next time.
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Stardog
Member
Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
thanks stardog. i will try this next time.
Sorry I'm such a jerk, guys. I needed to add that they should all be taken about an hour before pain medication, not at the same time.
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jandkwatts1
Stranger
Reged: 05/04/04
Posts: 9
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Quote:
Take a half pill next time. Some people feel very fine with 5mg, and nausea with 10mg.
i will try this as well. thanks for the advice.
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jandkwatts1
Stranger
Reged: 05/04/04
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skyrx
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dsmmcm
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Reged: 11/08/03
Posts: 361
Loc: southwest US
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There is no need to be so smug about it. Your own source classifies axid, pepcid and tagament as "MISCELLANEOUS GI DRUGS", not antihistamines.
D.
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jandkwatts1
Stranger
Reged: 05/04/04
Posts: 9
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Quote:
I'm guessing that the original poster is taking Hydro for the FIRST time, and is not used to any opioid; in which case 10mg is possibly a high dose.
He should try taking 1/2 pill, after all, most Drs initially prescribe no more that 5mg for even some post-op pain.
Also, if one needs all sorts of work-arounds to tolerate any medication; maybe they should try something else. Don't remember if his medical condition was mentioned....
yes, this was my first time. medical condition consists of back injury from almost 5 years ago that docs said would heal on it's on..never did. bad scoliosis, connective tissue disorder, cystocele, and lately, migraines. stress brings on a major lupus flare-up and all i wanna do is cut off my legs because my knee joints hurt so bad.
i just wanted to try something stronger but will go back to the ibuprofin and remember to take my plaquenil everyday.
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jandkwatts1
Stranger
Reged: 05/04/04
Posts: 9
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Quote:
Everybody will have a different reaction to different medication. For me, I get nauseated when I take any narcotic medication. The only thing that makes me feel alright is if I get plenty of fluids. I literally am constantly drinking water or some water type drink when I'm medicated or I'll get nauseous. Not saying this will help you, but you never know.
oh yeah, i drink about 3 gallons a day. i love water.
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Stardog
Member
Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
There is no need to be so smug about it. Your own source classifies axid, pepcid and tagament as "MISCELLANEOUS GI DRUGS", not antihistamines.
D.
What part of "H2-receptor antagonist" confuses you? The H2, of course, refers to the type 2 histamine receptor.
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dsmmcm
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Reged: 11/08/03
Posts: 361
Loc: southwest US
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I am not trying to argue with you. The chemistry is the chemistry (I understand that too). I also understand the common usage of the word antihistamine. There was absolutely no need to jump down the other poster's throat.
D.
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Stardog
Member
Reged: 08/28/04
Posts: 195
Loc: Where it all Begins
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Quote:
I am not trying to argue with you. The chemistry is the chemistry (I understand that too). I also understand the common usage of the word antihistamine. There was absolutely no need to jump down the other poster's throat.
D.
I apologize once again for being a jerk. I was jumpy and saw someone telling me I was wrong when I was right - what would you have done? His/her incorrect post was undermining the message that you can use OTC products to combat nausea, which I think everyone would agree is an important topic.
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dsmmcm
Board Addict
Reged: 11/08/03
Posts: 361
Loc: southwest US
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No problem. Enjoyed your posts on the John Edwards for v/p thread. Now there's a place you can really let it fly!
D.
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seaofyouth
Journeyman
Reged: 09/22/03
Posts: 77
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Junior? Wow, I am sorry to step on your know-it-all toes.My username does not reflect on my age in any way. I hope I didn't get you too upset.
You were right and I was wrong. Wow, What would I have done? found a more polite inobstrusive way of telling of your wonderfull triumph of knowlege. Now I am going to quietly go and slit my wrists.
*sarcasm off*
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lovely11
Board Addict
Reged: 01/03/04
Posts: 332
Loc: With my dog at my side
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I love you seaofyouth.
I think I'll join you in splitting my wrist, since obviously I don't have the knowledge it takes to carry on a civil conversation with certain others either.
Is that proper english? OMG!!!
--------------------
Lovely - devout dog lover
I wish I were half as good as my dog thinks I am.
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oothibo
Newbie
Reged: 07/13/04
Posts: 28
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There are two types of receptors in your body that interact with histamine:
H1 receptors are found mainly in blood vessel walls: this will interact with histamine and cause vasodilation and bronchoconstriction along with increased capillary permeability. This causes the redness associated with allergic reactions and a wheal to form (think of hives). This also will make your nose run (think allergies). Many 'anti-histamines' such as benadryl and dramamine will work by countering the H1 (they are H1 antagonists). They also can get into the CNS and decrease nausea associated with motion sickness (mainly Dramamine is used for this)
H2 receptors are found mainly in the heart and the stomach: in the stomach, when histamine binds to H2 it helps stimulate acid production. Hence, if you block H2 (with drugs such as tagament and zantac) you will have less acid production, and less stomach irritation.
What is probably causing the stomach irritation you are having with the hydrocodone/APAP is due to the Tylenol (APAP). Tylenol inhibits the COX enzymes which are also protective of the stomach linings. Like everyone else on this post has said, you should try decreasing the APAP to 500mg or less and see if this would help. Also, taking an H2 blocker might be beneficial b/c this will help decrease the acid production in the stomach.
There is a chance however that the opiod (hydrocodne) is activating the brainstem chemoreceptor that is involved in nausea and vomiting. Not really sure what you would do to prevent this.
Hope this cleared some stuff up :-)
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