poppyale
Member
Reged: 06/15/04
Posts: 131
Loc: united states of america
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Are there any potentiators for hydrocodone?
just curious
poppyale 
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Trampy
Pooh-Bah
Reged: 04/02/02
Posts: 1230
Loc: Southwest U.S.
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Yes, but DB usually doesn't like it when we talk about them. They say it violates their rules.
Do a search here for the past year and you can find posts they didn't delete. Most of the information is gone, though. It's a waste of time to write the same stuff that's already been deleted many times. I've had discussions about it with the board owner who after hearing that opiate potentiators are used by doctors and drug companies and are part of FDA-approved drugs and drugs in FDA-approved clinical trials ... well, then he agreed to allow some posts on the subject, but by that time i'd already had too much of my writing discarded and decided it's not worth the trouble of writing it again. Please don't PM me for info on this because i won't reply. Use Search to find what's left ... if anything. Look on the VIP side too if you're a member.
Edited by Trampy (08/11/04 10:25 PM)
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peteg72
Member
Reged: 05/10/04
Posts: 174
Loc: midwest
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Trampy... Where the heck have you been?
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And if the band youre in starts playing different tunes....I'll see you on the dark side of the moon
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spongemom
Journeyman
Reged: 07/12/04
Posts: 55
Loc: Tennessee
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Whats a potentiator?
sorry for the dumb question
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OOOOOOh.... who lives in a pineapple under the sea. Absorbent and yellow and porous is he. If nautical nonsence be somethin' you wish.. then drop on the deck and flop like a fish
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trixxie
Member
Reged: 05/23/03
Posts: 122
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meds/or OTC products or foods that increase the effectiveness.
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The truth shall set you free!
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timberland
Enthusiast
Reged: 07/10/04
Posts: 236
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Quote:
Are there any potentiators for hydrocodone?
just curious
poppyale
Grapefruit juice, Advil, and Aleve are OTC potentiators if you take them 45 minutes to an hour before you take hydro.
Take claritin in the morning to get rid of some of the side effects that can interfere with analgesia.
Take Pepcid AC at night because it resets your body for hydro the next day. If you want to know why, check some of my previous posts.
Timber
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IMSUSCOT1
Threadhead
Reged: 10/23/02
Posts: 875
Loc: usa
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actually grapefruit juice works with benzos--there's an enzyme in the stomach it either blocks or doesn't....don't think I've ever heard the same thing on hydrocodone.....
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timberland
Enthusiast
Reged: 07/10/04
Posts: 236
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Quote:
actually grapefruit juice works with benzos--there's an enzyme in the stomach it either blocks or doesn't....don't think I've ever heard the same thing on hydrocodone.....
You're talking about CYP3A4, and it's in the intestine and mostly in the liver, not the stomach. CYP3A4 and CYP2D6 act on hydrocodone. CYP3A4 inactivates it, while CYP2D6 turns it into Dilaudid. Which would you prefer?
The point is, blocking CYP3A4 inhibits its inactivation, and leaves more for CYP2D6 to turn into Dilaudid. It is generally thought that hydrocodone must be turned into Dilaudid to have effects, but some studies have shown that hydrocodone is active by itself. But no matter what, if CYP3A4 gets to it, there's less hydro or Dilaudid for you to enjoy.
Blocking CYP3A4 with grapefruit juice means a higher hydro level in the blood.
I'm actually kind of actually tired with people telling me, "actually, this or that.." when actually so few of these people have actually been accurate. Please don't post unless you KNOW WHAT YOU'RE TALKING ABOUT!
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