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Meds, Medical Conditions, and Treatment >> Meds, Medical Conditions, and Treatment

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tone
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Myths & Facts about Tramadol (Ultram)
      #163883 - 05/21/04 10:44 PM

Tramadol is a drug that is more commonly known by one of its brand names: "Ultram"


Myths & Facts about Tramadol (Ultram):
By Tone


Myth: Tramadol is not an opioid / narcotic (narcotic is a strange misnomer word for opioid that caught on)

Fact: Tramadol is an opioid and its metabolite has 200 times more affinity for mu opioid receptors than the parent compound. people who metabolize it well via CYP2D6 pathway may experience more opioid-like effect from it.

Myth: You cant get withdrawl from stopping tramadol, or the withdrawl is barely anything compared to hydrocodone

Fact: Tramadol withdrawl is an agony hell of misery that can include extreme depression, dysphoria, terrible restlnessness and insomnia, sweating, nausea, anxiety, panic, and inability to do anything but lie around and suffer in torture.

not all people have severe withdrawl to tramadol, but then again not all people get strong effects from it either and people also vary in how bad they withdrawl from hydro.

Myth: Tramadol cant be all that great of an opioid, otherwise it would be controled

Fact: There are people who actually prefer tramadol over hydro or oxycodone, me being one of them. status of a drug does not affect that drug's properties and the DEA doesnt always schedule everything that works, not yet at least, who knows, maybe tramadol abuse will be observed more and it will become scheduled. i hope not.

i believe for some people hydrocodone works much better, but for most hydrocodone works a little better.

Myth: Tramadol works because it has serotonin and noradrenline properties like an anti depressant, the opioid effect is so tiny its not really significant.

Fact: yes, tramadol does inhibit serotonin and noradrenaline reuptake, but did you know that its metabolite was found to be 6 times better at analgesia in animal studies than the parent compound? What a coincidence, the metabolite is also the one thats 200 times more of a Mu Agonist.

Myth: Tramadol may cause seizures, but i have read that other opioids in high doses have caused seizures, so that must be why.

Fact: Tramadol is more convulsive than regular opioids and its reasonable to say its due to the other non-opioid mechanisms. when people are given an opioid antagonist like naloxone during a tramadol induced convulsive episode, the episode actually gets worse, therefore its not the opioid mechanism, which actually helps.

Myth: Tramadol is good for quiting other opioids

Fact: well duh, its another opioid, but then you have to quit the tramadol. since its easier to get this may be an option if you cant get the other opioid anymore, that way you could switch to tramadol then take your time tapering.


Myth: i should by Ultram brand tramadol, it will work better, because the name on the bottle is Ultram

Fact: Tramadol HCl is Tramadol HCl no matter what the brand is. i have used 4 brands of tramadol from both US and over seas and i cant tell the difference.

Myth: if i grind or chew up my pills, they will kick in faster and it will be better

Fact: what are you talking about? this is only true if its a time released pill with a coating or something. you can do that if you want, i mean, it might make it kick in 30 or 45 seconds faster.

Myth: things that potentiate hydrocodone will work on tramadol

Fact: what!? remember, tramadol needs to be metabolized well like codeine does, so if any of the potentiators you are talking about are CYP2D6 Inhbitors, i would just forget about them.

Myth: to get best results, you must get ultram brand pills, crush them into a very very fine powder practically a gas, place them in Dr Pepper, take it on an empty stomach, take allergy pills and have a positive attitude

Fact: i shouldnt even need to answer this one.


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mikevx
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Re: Myths & Facts about Tramadol (Ultram) [Re: tone]
      #163903 - 05/22/04 12:27 AM

Good info amigo.

Quote:

place them in Dr Pepper, take it on an empty stomach, take allergy pills and have a positive attitude






For me, tramadol helps with no pain. Not even a headache. I feel no 'euphoria' effects. But one thing it does do is something you mentioned in another thread here also. Something that is rarely (if ever) mentioned as an effect. It does help sometimes with anxiety/depression. For that reason I'll always have some around.

--------------------
"cowards die many deaths, the brave only one"


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want2bcalm
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Re: Myths & Facts about Tramadol (Ultram) [Re: tone]
      #163904 - 05/22/04 01:17 AM

Thanks for all your info. I got a huge laugh out of the "crush & put in Dr.Pepper" WTH? How bizarre. I am with you. I do believe some people metabolate Tramadol as a strong opiod. I am currently going through w/d exactly as you described. Pure h---. The most odd thing I find about it is that I was honestly only taking 100 mg a day in the AM for morning low back ache. If I took more later in the day, I could not sleep & that is another problem I have.

I have gone through long periods not taking it after having taken it for a long time (at only 100 mg/day) & DID NOT experience any w/d. This is probably the second time I've experienced w/d & the other time I had been taking larger doses.(but still only 200-250 mg day--4or5 50 mg. prescribed for severe pms pain). That w/d was worse than this one but not by much.

One doc gave me Vicodin & I didn't like it as well as Ultram. Ultram did NOT give me a euphoric feeling. Honestly, I really didn't think it did much after awhile. It did help somewhat at first w/the low back pain (w/PMS) & it would kind of prevent it (from the night time crummy bed) if I took it first thing in the AM. I guess I was an idiot & didn't realize that my body was dependent even on a low amount.

I don't know what to do? If I get through this & can live w/out the 2-50 mg/day. No problem. Otherwise I will have to rely on OP's since I have moved & will have to find a new OB/GYN to deal with the PMS pain/symptoms. The last one put me on Prozac. Yuckky, yuckky for me. She honestly said she handed them out like M&M's & everyone thought they were the miracle cure. Honestly they made all my symptoms worse--irritability, sleeplessness, pain, headache, blah,blah,blah.

Sorry for this BORING post. Just know that Tramadol is NOT a harmless sub for Hydro.


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tone
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Re: Myths & Facts about Tramadol (Ultram) [Re: want2bcalm]
      #163909 - 05/22/04 02:13 AM

hang in there it WILL go away and youll be fine. it might last just a little bit longer than hydrocodone withdrawl does but youll be fine in no time

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oldnavy170
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Reged: 05/12/03
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Re: Myths & Facts about Tramadol (Ultram) [Re: tone]
      #163925 - 05/22/04 07:17 AM

All Tramadol did to me is make me throw-up and ALOT!!!!!!!

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night_shade
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Re: Myths & Facts about Tramadol (Ultram) [Re: want2bcalm]
      #163927 - 05/22/04 07:25 AM

want2bcalm...

I sent you a PM explaining tone's joke about the Dr. Pepper. You weren't here yet when that thread was in play...so don't feel mystified any longer!

--------------------
Never underestimate the predictability of stupidity.


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14stones
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Re: Myths & Facts about Tramadol (Ultram) [Re: night_shade]
      #163996 - 05/22/04 04:17 PM

During a very nasty ct/wd from h/10s on the fourth day I was given 16 "ultracet" to take for pain. They took the edge off of the wds and for that I was greatful. They also only made my wd last that much longer.

Of course they would because, as tone said, they are an opiate. I took those 16 over a ten day period (ultracet has 37 m of tramadol in them added with apap) and got down to taking a half in the late afternoon and a half at bedtime.

I would rather have taken that one a day (in halves) at the end of the day looking back but, that was that.

I did notice that at the end of taking them that my pain was worse for a day or so and then it all got better.


For those who take Tramadol, it is a great option to hydro. I would also say that it, like anything in life, has the potential to develope into a dependency. Be very careful.


Tone, if you would like some great med support I found on using stimulants during and after your wds (non presecription types) let me know via pm. I found some truly smart articles on the subject.

Jama has one even.


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Trampy
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Re: Myths & Facts about Tramadol (Ultram) [Re: 14stones]
      #164005 - 05/22/04 06:12 PM

As far as its non-scheduling goes, there might be some old-timers who were on alt.drugs circa 1998 who remember the discussions about how FDA was monitoring the USENET newsgroups (where all the action was): like alt.drugs, a.d.chemistry, and a.d.hard. Someone actually found posted on an FDA site Ultram's complete review panel minutes where they had discussed its abuse potential. FDA had had a staff member monitor the internet for discussions about its abuse potential and since most of the regular posters were only interested in drugs stronger than hydrocodone, the USENET consensus was that they weren't interested in Ultram. The FDA even said that some of the posters seemed as knowledgeable as their own pharmacologists. This was the first time in our knowledge that anonymous anecdotal reports on its effects and discussions of its chemistry that were found on the internet played a crucial role in the decision to not schedule a new opioid analgesic. The FDA report quoted "Samson" who was one of the resident experts on opiate drug chemistry back then. He was very upset to see himself quoted by the FDA for that purpose, but was glad they decided not to schedule it.

They didn't base the decision only on those USENET posts. They also did the standard abuse-potential trial where they did a double-blind crossover study and gave tramadol, placebo, and a strong opiate to a small group of experienced opiate users. (There was quite a buzz about how they could enroll in those studies!) Anyway. the opiate users reliably detected placebo and also strongly preferred the "real thing" to the Ultram. So that's the background of why Ultram was not scheduled.

Trampy

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Your mileage may vary ...


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tone
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Reged: 06/29/03
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Re: Myths & Facts about Tramadol (Ultram) [Re: Trampy]
      #164008 - 05/22/04 06:28 PM

well the thing is, Ultram doesnt have a hard quick rush of euphoria that other opioids can produce. but i still prefer it and it still has withdrawl. of course there are lots of other things that can produce withdrawl and are not abused, such as paxil

thats very intersting trampy, i thought they would monitor. they made the right choice about ultram, the other poster is absolutely right about it not being able to create a rush so i can see why its not abused nearly as much


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LumbarSpasm
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Reged: 05/07/02
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Re: Myths & Facts about Tramadol (Ultram) [Re: tone]
      #165715 - 05/31/04 12:36 AM


Tone, I put tramadol+myths into a google search and this is the page that showed up: http://www.google.com/search?hl=en&ie=UTF-8&q=tramadol+myths&btnG=Google+Search

Tone, you're gonna get popular that way.

--------------------
LumbarSpasm
Or just a pain in the butt?!


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ePharmacy
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Re: Myths & Facts about Tramadol (Ultram) [Re: LumbarSpasm]
      #165763 - 05/31/04 11:19 AM

Oh man Tone. Nice work!

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