kimbell1
Board Addict
Reged: 08/20/03
Posts: 306
Loc: Route 666, Painville, Texas 6...
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There are new pain killers coiming designed to eliminate the euphoria caused by the drug.
I could add my own opinion, but I am curious what readers think-does it take the euphoric properties for a pain reliever to really kill the pain?
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pickles
Journeyman
Reged: 11/09/03
Posts: 55
Loc: Indiana
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I believe any med that blocks pain receptors will create "euphoria"or "sense of well-being".Though,there are already meds in existence(talwin-nx etc.)that don't give us that feeling of well-being,but in my experience with these antagonist meds,they are basically useless!Even Darvocet,it kills the pain but makes me feel downright awful,such as nasty metallic taste in my mouth similar to Ultram.
I have no problem with a little euphoria myself,though i get very little,as being on opiate therapy for 8 years now.When i describe my personal euphoria i would compare my first dose in the morning before work as to a hot bath when you first get in the tub that soothing relaxed pain-free euphoria so-to-speak.Although it is my first dose in the morning that i feel that well-being state of mind.
Another thing i will add is that there is also a fine line between relief and euphoria,i wish doctors could understand this.When the mouse pulled the thorn outta the elephants foot,the elephant was not so high that he hugged the mouse afterwards,he was just relieved.
One last thing,i'm sick of the somewhat double standards with society as well,it's okay and legal to purchase a pint of vodka over-the-counter and drink until you get so much EUPHORIA that you can wipe-out a mini-van full of an unsuspecting family of four,but chronic pain sufferers aren't aloud to feel a little better than normal without being scrutinized!Drunks are looked at as "upright citizens" but pain sufferers are looked at as "weak"!
Apologize for rambling!
Darn good topic KIMBELL !
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BDWhiteCloud
Stranger
Reged: 08/22/03
Posts: 8
Loc: South LA.
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Oh this is good.I am on pain med's going on 19 years.I do not get no buzz just some relef.
so meany peppel I know do not understand that if I take med's and I am up and moving that I must have A buzz.Not true JUST SOME RELIFE
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BFThornberry
Journeyman
Reged: 01/23/04
Posts: 86
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Assuming that the med works as well on pain - as far as I am concerned - No Euphoria - No Abusers - No DEA problems - No questionable looks - Not as much $$$$$$$$$ -
BRING IT ON!!!!!!!!!!!!!!
I have said before that I personally HATE the Euphoric
feelign that sometimes accomponies my pill because when it does happensI know that I'm going to feel tired in a little while too. It's more of a rollercoaster. I'd rather have something that takes the pain away for like 12 hours at a time that you can take at 8 hours if needed that you can't get high from if you tried smooshing it up, boiling it, stomping on it, screaming at it and then injecting it in your eyeball - just so it's really easy to get!
JMHO
BRIT
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oldnavy170
Board Addict
Reged: 05/12/03
Posts: 357
Loc: New York
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Quote:
Assuming that the med works as well on pain - as far as I am concerned - No Euphoria - No Abusers - No DEA problems - No questionable looks - Not as much $$$$$$$$$ -
BRING IT ON!!!!!!!!!!!!!!
I have said before that I personally HATE the Euphoric
feelign that sometimes accomponies my pill because when it does happensI know that I'm going to feel tired in a little while too. It's more of a rollercoaster. I'd rather have something that takes the pain away for like 12 hours at a time that you can take at 8 hours if needed that you can't get high from if you tried smooshing it up, boiling it, stomping on it, screaming at it and then injecting it in your eyeball - just so it's really easy to get!
JMHO
BRIT
Whats good for one person is not always good for another so why don't they allow the patient to make that choice. 
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Greycie
Old Hand
Reged: 07/08/03
Posts: 466
Loc: Pacific NorthWest
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I agree with Brit... but for myself. I too prefer no euphoric feeling- just relief of my pain. I prefer to remain lucid. I won't drive medicated because my judgment is impaired and there is so much I can't do if medicated and so much I can (physical limitations- though I accept no limitations for myself) without it.
Edits: Yes, I have to come clean up my typo's... sorry, broken finger, lol.
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"I may not agree with what you say, but I will defend to the death your right to say it." - Voltaire
Edited by Greycie (05/13/04 07:14 AM)
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johng
Board Addict
Reged: 02/13/03
Posts: 358
Loc: great lakes
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I dont get much euphoria from the med itself it is just the sense of releif that the pain is going away
john
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Ask and it will be given to you Matthew 7:7
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oldnavy170
Board Addict
Reged: 05/12/03
Posts: 357
Loc: New York
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Quote:
I agree with Brit... but for myself. I too prefer no euphoric feeling- just relief of my pain. I prefer to remain lucid. I won't drive medicated because my judgment is impaird and there is so much I can't do if medicated and so much I can (physical limitations- though I accept no limmitations for myself) without it.
I feel that Night_Shade made a great point in this tread.
https://drugbuyers.com/freeboard/showflat.php?Cat=0&Board=conditions&Number=161663&Forum=
(Sorry I don't know how to make it a short link)
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Greycie
Old Hand
Reged: 07/08/03
Posts: 466
Loc: Pacific NorthWest
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Ohhh... can you edit out my typo's, navy? LOL! My own grotesque grammatical faux pas are one of my biggest pet peeves! Even if it is on account of the finger 
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"I may not agree with what you say, but I will defend to the death your right to say it." - Voltaire
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night_shade
Threadhead
Reged: 08/26/03
Posts: 907
Loc: The State of Hockey
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Oldnavy was referring to this quote from another thread:
Quote:
Another thing to point out is that MANY people equate the euphoric effect of opioids to whether or not it is "working." The euphoric effect is not synonymous with the drug's analgesic effects!
I have noticed that I tend to feel more of the "euphoric" (I put this in quotes because I don't actually get a euphoric feeling from it--ever--it's more like the slight warmth and tingles for a little bit only, like another poster said, after my morning dose) when I am not busy doing something. For example, if I have errands or a project that I start on right away in the morning, I rarely notice any effect at all other than moderate pain control. Or, rather, that I notice the lack of pain exacerbation which would normally be the case if I didn't have my meds. The euphoric effect of opioids, thankfully, has little to do with analgesia. If it weren't the case, those of who have been on opioids for many years would never be able to obtain pain relief from anything other than obscenely high doses.
Just my opinion.
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Never underestimate the predictability of stupidity.
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tone
Veteran
Reged: 06/29/03
Posts: 554
Loc: Chicago
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first to pickles: pain meds dont block pain receptors and create euphoria, but rather, they inhibit gaba on dopamine neurons in the midbrain, and this causes those dopamine neurons in the pleasure pathway to fire more. that causes the euphoria and this is known as the excititory effects of opioids.
as for the question of should they cause euphoria. If all a person needs is pain relief, there is no reason for them to have to cause euphoria. Is there a problem with them causing euphoria? not that i can see, the problem is they cause withdrawl upon stopping, not that they cause euphoria upon starting. withdrawl is the problem that should be focused on, who cares about euphoria. withdrawl causes pain. euphoria doesn't. therefore withdrawl is more important to get rid of.
does a painkiller need euphoric properties in order to work the best? yes it probably does, since the same thing that causes euphoria is also the thing that causes your perception of pain to be altered, so the pain doesnt bother you anymore. willing to bet new pain killers that cause less or no euphoria wont kill pain as well
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Dyno
Journeyman
Reged: 03/23/04
Posts: 89
Loc: Washington
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I agree with Tone. pain and pleasure points in the brain
are related and with out one of the elements the other will not work as well.
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Wishing all pain free days D.
Edited by Dyno (05/13/04 01:45 PM)
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Sky_Queen
Fly Girl
Reged: 12/03/02
Posts: 1967
Loc: Texas
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What an interesting post! I have always said that living in chronic pain is so awful, so depressing, so sad....I always thought that the little euphoria I *might* get from time to time is the ONE reward of having to take these awful pills to begin with. I would give anything to not have to take these "roller coaster" pills. Just my .02.
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orgart
Member
Reged: 01/02/04
Posts: 167
Loc: calif
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In a perfect world you would take a pill that perfectly matched the level of pain you were in and there for would leave you normal. In this world we hit and miss with this concept and for the most part we go over a little bit just to put us ahead of the pain. If this lets one feel the effects of the drug then so be it. This is not a perfect world, as we all know, and we didn't choose to be in pain so we have to deal with the condition the best way we can. I myself work a seven day work week (doing what I love) and the slight dullness created by my meds tends to be over looked for the most part. I'm only hoping I can always work.
everyone feels things in their own way
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orgart
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uga81
Enthusiast
Reged: 02/10/03
Posts: 223
Loc: North Georgia
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The roller coaster is a pain. I would like to get up in the morning just not wanting to get up like everyone else in the world. But, then body parts start hurting and I take my medication and the parts stop hurting. No pain is a high. If I could do it without the roller coaster I'd be fine with it all. It doesn't have to be hydro. If Aspirin took away the pain, I'd use it and nothing else. Highs are for college students and the gutter trash.
I vote for a pain killer with no side effects but killing the pain! 1
Barney
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"Life is tough. It's tougher if you are stupid." John Wayne
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buey
Old Hand
Reged: 01/15/03
Posts: 453
Loc: USA
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If there was an effective and safe pain reliever out there without the potential for euphoria, I'd take it. I have tried what seems like almost all pain relievers on the market, from aspirin to Percocets. Hydro works best to stop my pain. I don't need oxycodone, and the hydro actually works better for me.
I've tried the latest and greatest drugs that tout that they are just as effective on pain as a narcotic but without the potential to be habit forming. If only they actually worked. I still take Ultram when my pain does not warrant hydro. But the last "breakthrough" medication that my doctor gave me that fit the bill of being effective/non habit forming was pulled off the market because people were dying from it. The name of the drug was Duract. got a call from my pharmacist one night to tell me to go off of the drug and either flush them down the toilet, bring them back and go to my doctor the next day for a liver panel. Scary stuff. I'd rather use what has been proven safe and is effective for me. If it has the potential to cause euphoria, oh well. That's not what I am after and I seldom get euphoria from narcotics anymore. Those days are long gone.
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yawkaw3
Pooh-Bah
Reged: 03/22/03
Posts: 1193
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The thing is though, how do you define pain? Is this magic painkiller supposed to take a swing at all kinds of feelings that we perceive as pain- like opiates do? There is of course emotional pain to take into consideration- is a drug that provides relief from emotional pain causing a high?
I think we are very far away from a drug that will work on all kinds of physical pain- there are so many different types of physical pain. A drug that handled inflammation might be useless on a person with neuropathic pain.
A drug that relieves some inflammation, like a Cox-2 inhibitor, is working on the physical source of the pain- whatever inflammatory disease. An opiate is taking care, not of the actual source of pain, but on the brain's perception of it. Any drug that is dealing with the brain's perception of pain is going to take care of all feelings we perceive as pain- and that's what we have with opiates to some extent. We are nowhere close to understanding how to only affect the brain's perception of physical pain.
I think along with real chronic physical pain comes some emotional pain. I don't know that people would be so happy with a drug that didn't affect emotional pain, like they think they would be. I think that would be a huge psychological adjustment to make and a lot of people wouldn't take it, as the psychological issues surrounding chronic pain become more and more pronounced without the anesthesia opiates provide.
What is a better idea, IMO, is an opiate that doesn't cause physical withdrawal. You can't stop a person from being psychologically addicted to something- that's pretty tough for a drug that could relieve psychological pain. But if it didn't cause physical withdrawal, it would be easier for someone highly motivated to get off it without much trouble. We're nowhere close to that either, though, William S. Burroughs said in Naked Lunch that whatever function of opiates causes the high/pain relief is probably also responsible for the addictive nature, and that the two could never be separated.
-yawkaw
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leila01
Journeyman
Reged: 09/22/03
Posts: 96
Loc: pennsylvania
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I agree with a couple people in that the moment you happen to feel a small sense of euphoria, you can bet that you will be tired shortly after. The tiredness ALWAYS outlasts the euphoria. So, more pain relief, no euphoria!!!!!
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HERC
Newbie
Reged: 03/29/04
Posts: 35
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Yawkaw as usual you get to the heart of it.I know as a lomg time opiod user there is no one size fits all drugs.MANY DRS however beleive that it is.Example:one of my old pcps started getting a lot of dihydrcodeine samples from a drug rep and was handing it out like candy,at the time i was on endocet,he was raving about how many patients were getting relief and wanted me to try it.He also gave me my script for endocet.Well the dihydro gave some relief but not nearly enough.So when i go back to him we discuss it and he concluded the severity of my injuries did need more stronger meds than others and actually stated he would take more time considering appropriate medication for his patients than just to hand out the newest thing. This dr evenyually had to move to another state to practice because of pressure he was under trying to help pain patients.Back to it though.my own feeling is there are combinations that will work .Itried every anti imlammatory drug there was and none worked till i was put on vioxx.And i see a lot of people say it helps them none.Our body chemistry is all different,thats why if you have something that works stick with it. If noy keep searching maybe you'll open that magic combination that works best for you.As for euphoria that usually ends after a certain time anyway.Untill the time they can make a synthetic drug for pain without opiates that all can use which i dont see happening people are still going to get a slight buzz.Idont think we will ever see that one magic pill that helps every person
Edited by royj (05/14/04 07:07 AM)
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LumbarSpasm
Silent Chaos
Reged: 05/07/02
Posts: 1538
Loc: USA
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I'd be happy with pain relief period.
Then if I found there was a psychological aspect to my pain (and surely there is but I can't prove it to myself) I would set about addressing that too.
I do not believe euphoria is a necessary component to pain control, and for patients on a long term opiate regimen the euphoria goes away as tolerance builds.
Getting rid of dependence and withdrawal would be wonderful.
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LumbarSpasm
Or just a pain in the butt?!
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dsack
Veteran
Reged: 01/20/02
Posts: 535
Loc: midwest
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I think the euphoria is part of changing a person's perception of pain.
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uga81
Enthusiast
Reged: 02/10/03
Posts: 223
Loc: North Georgia
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Psylin
Excellent idea about the "No withdrawals"! Add "No tolerance buildup" and you have a wonder painkiller they could sell out of gum machines.
Barney
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"Life is tough. It's tougher if you are stupid." John Wayne
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