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Meds, Medical Conditions, and Treatment >> Meds, Medical Conditions, and Treatment

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flea
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Oxycontin & Methadone?????
      #159429 - 05/04/04 02:36 PM

Hi all,

Just wanted to kow if anyone knows if it is really bad to take these 2 together, and or if they may counter act one another; ie......does this combo make either drug less effective?

I know that methadone is not meant to be taken at the same time as any other narcotics (or at least I can only imagine this to be the case) but someway, somehow I managed to royally mess myself up this month in terms of the dose of meds I had taken.

This had never happened before as I have been on the oxy's for over a year now and have basically been really good with keeping "right on target" with my prescribed monthly doses of both meds. Even as I developed a higher tolerance for the meds, my doctor was not comfortable with keeping me at the originally higher dose (that she initially started me at) so even at the start of my treatment with her.........(she's just my family doc, not even a pain doctor, which in itself is amazing as my pain doctor WOULD NOT prescribe me the oxycontin and was such a jerk about it. He was mean and nasty and because i had been the one that had asked my family doc for the referral to the pain clinic, I could do nothing but blame myself for ever going to him in the first place. After he told me he felt I was a "drug-seeker" which blows my mind since before going to him I was already being prescribed pretty strong narcotics from the very doctor that I asked to send me to him, so why would I come seeking drugs from him when I already could get them????? Sorry, little flash back there, I just get so angry!!!)

This pain doc even had the nerve to call her and tell her he felt she should no longer prescribe narcotics to me and that I should immediately be pulled off, and go into immediate treatment, COLD TURKEY! But thank GOD she felt strongly that he was incorrect about me and that I was not a "drug-seeker" as he had suggested, but rather someone she had seen prior to this back pain and failed back surgery and I was never seeking any kind of narcotics at that time. It was not until I was suddenly struck with this chronic pain that I started taking pain meds, so there jerk!!

Anyway my point is that she went out on a limb for me and believed in me, so I have wanted to whatever she asked of me, even if thst meant lowering my doses every couple of months, even while I was getting a higher tolerance level going on.

So now, to my question, goodness, do I always have to give such a looong back story? SORRY! Anyway......as I mentioned earlier, I did mess up this month for some weird reason, because my back pain had suddenly started hurting far more than it had been before, (or maybe my tolerance level grew more, I don't know) but what I ended up doing is taking more than I was supposed to in the beginning of the month, somehow thinking I would be able to equal it out later on. But I wasn't able to. So now i have 10 more days until I have to see her and then get my refill, but I am going to be out of them far sooner, even at a highly reduced amount each day that I have now been taking. I am already feeling withdrawl syptoms because of the last several days my dose has been lowered in my "attempts" to "equal out" the rest of my meds. I am at the lowest dose I can possibly take right now, and because that will still not give me enough to make it the whole 10 days (maybe like another 4 days or so) therefore I am going to be stuck those 6 days or so with nada!!!! What am I going to do?

I know that oxycontin has a pretty long "half life" (is that what its called?) but that has not helped all that much with my withdrawl right now, and its only been a few days with a decreased dose, so what will I possibly do when I have to go 6 days without anything left?

Therein lies the question. I have several methadone left, so last night in the middle of the night when I felt like my skin was crawling, i decided to take one of the oxycontin with a couple of the methadones to see if that may help out for the time being, and maybe i would somehow be able to balance the 2 together and maybe, just maybe make it through the next 10 days without going completely out of the oxycontin.

But do they counter act one another or not? Is it worthless to try or even worse, can it make me even sicker?

If anyone has any advice I would greatly appreciate it.

Thanks

--------------------
Flea



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Packersfan
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Reged: 02/28/04
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Re: Oxycontin & Methadone????? [Re: flea]
      #159441 - 05/04/04 03:16 PM

Flea,

I personally was on Duragesic 75 + Oxycodone x 3 tablet/day for one year. Last week I went to my Pain Doc and questioned a possible tolerance to the meds.

He then gave me Methadone! I, like so many others out there, thought that Methadone was for the heroin addict to prevent w/d's. NOT! Methadone is now a recognized Schedule II med for Chronic Pain. Well, I came home and took 1/2 of a 10 mg. tab as directed. I was BOMBED!! I phoned the doc's office after three 1/2 tab doses over the next 24 hours and told them I couldn't function. (Keep in mind I've been on Schedule II meds for 3 years, but the patch + Percocet combination for one year--meaning I'm not opiate naive). My point is to those who say Methadone gives you no "high," hogwash!! It gave the most bombed feeling I've ever had from meds.

My point is that I was still wearing the patch (as I was instructed to do), when I started the 1/2 tabs of 10 mg. Methadone. I was then instructed to remove the patch and report back in 12 hours (the patch would have been working for 12 hours after I took it off).

The next a.m. I phoned and felt like a million bucks after I removed the patch.

My point is that unless specifically ordered, I would NOT take two long acting drugs in conjunction with Methadone--notta, no way, no how.

I asked my doc to give my Percs back for breakthrough, but he will not give any more drugs in conjunction with Methadone, as according to him, "Methadone is the strongest medication available."

Initially I was kicking myself for even mentioning tolerance, but now that I have adjusted to the Methadone (and am on the proper dose), I am doing much better mentally AND physically with my pain than I ever was on the Patch + Percocet. It's amazing how scared I got knowing that my meds were going to be changed!! Now I'm happy they WERE changed. In fact, he said that changing meds every 2-3 months alleviates the tolerance issue.

JMO, but I would not take Oxycontin with Methadone unless Rx'd.

Hope this helps!


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JayStraw
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Reged: 12/13/03
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Re: Oxycontin & Methadone????? [Re: Packersfan]
      #159443 - 05/04/04 03:21 PM

the methadone will block some of the effect of the Oxy, but it will not make it worthless for sure!! Especially if you are in pain.
BE CAREFUL THOUGH!!!! That's 2 REALLY strong meds and can cause SERIOUS breathing difficulties without you ever knowing if you take them at the same time.


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night_shade
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Reged: 08/26/03
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Re: Oxycontin & Methadone????? [Re: flea]
      #159519 - 05/04/04 07:50 PM

First of all, you have the misconception that Oxycontin has any added half life to its active ingredient, oxycodone...it doesn't. The oxycodone in OxyContin has the same half-life as that of the oxycodone in Percocet. The ONLY difference is the way the tablets are formulated to deliver it slowly over a period of time whereas the formulations of OxyIR or Percocet deliver the entire dose within an hour. Oxycodone itself has a SHORT half life--about 3 hours (but females have, on average, plasma oxycodone concentrations up to 25 % higher than males on a body weight adjusted basis.) For all intents and purposes, OxyContin is simply the extended-release version of OxyIR and the oxycodone in both formularies has the same general physiological effect on the body.

Secondly, you don't mention doses of either drug or whether or not the methadone and OxyContin are normally taken concurrently. Therefore, I will make the assumption that they are generally NOT prescribed FOR YOU to be taken concurrently and that you had some methadone tabs left over from a prior prescription, or some such thing.

I am concurrently prescribed methadone AND OxyIR by my pain doctor. In fact, I now have regular prescriptions for OxyIR, Percocet 10s (added this weekend for the acute pain from my new fracture of L3) and methadone. I never take more of any of these meds than is prescribed, so I don't know if your situation may contribute to any adverse effects while using the two drugs concurrently.

In my situation, the combination of oxycodone and methadone induces NO withdrawal symptoms. It is extremely effective for my acute and chronic pain. They work perfectly symbiotic together in my situation.

Unless you are taking more than 50-75mgs of methadone at a time, I don't believe you would experience any problems with it displacing the oxycodone in your system.

And I've been on methadone almost a decade and have LOTS of experience with this combination, so it really isn't guesswork on my part. But everyone is different.

--------------------
Never underestimate the predictability of stupidity.


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fred_s
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Reged: 11/18/03
Posts: 185
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Re: Oxycontin & Methadone????? [Re: night_shade]
      #159527 - 05/04/04 08:16 PM

Night_Shade...you've been on methadone for over a decade?
Ugh! It's a good med for chronic pain - but withdrawal is difficult. I have a friend on 300 mg per day for chronic pain and I'm worried about his taper schedule. It had better be couple years long at least.

But I concur, he gets oxyIR 5mg for breakthrough pain, and they work together pretty well.

--------------------
"One Lives But Once In This World"
- Johann Wolfgang von Goethe


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night_shade
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Re: Oxycontin & Methadone????? [Re: fred_s]
      #159537 - 05/04/04 08:35 PM

I have NEVER had tolerance develop from methadone. NOT ONCE! In fact, I reduced my dose from 100mgs/day to 30mgs day because I didn't like feeling so sedated.

People who are worried about tolerance should look into methadone for chronic pain.

--------------------
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tray1
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Reged: 11/22/03
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Re: Oxycontin & Methadone????? [Re: night_shade]
      #159593 - 05/05/04 04:31 AM

Night,
I have contimplated going to a Dr in my area that is compassionate but seems to prefer Methadone for Pain Management, Meth makes me very nervous to say the least, I know several people that are on it and get better pain relief then from any other med including OC, But I have also heard that Meth is extremely hard to withdraw from, the way I understood it was it was the worst, you seem to have a different opinion, It looks like there is not going to be a surgical option for my Radiculopathy, but my other problems may be surgically solved, the nerve damage is the bad pain its in my lower back and never goes away, only is quelled by the Hydro.......somedays I am unable to get out of bed, I REALLY need to get back to myself, I need to get back to work and my social life, I feel like I am missing so much, watching my life just go by never mind the debt I am getting into, what is your honest opinion about methadone maint.? Maybe too strong for me? Im really scared of it but I also want to function.......if you have a spare moment could you pm me with your thoughts? BTW the strongest med I have been on so far is Endocet 7.5 but even that did not take the pain away, came the closest, but not even 75% relief......

Tray


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night_shade
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Reged: 08/26/03
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Re: Oxycontin & Methadone????? [Re: tray1]
      #159652 - 05/05/04 08:56 AM

Tray-

Just to clarify- I am not on methadone maintenance, my methadone is prescribed by a pain management physician. I was, however, on MMT for years as a last resort to pain management (and perhaps a bit of naïveté.)

For me, with my chronic and degenerative conditions, "getting off" the methadone is not a concern. I will need it for life. But I DID do the methadone detox from the MMT program (at my wish and desire to do so) and it took me two years to complete. It can be accomplished with relative painlessness as long as it is done VERY slowly and with medical support.

But again, I find very good pain control with a combination of methadone, oxycodone and elavil. I also have other meds such as diclofenac and muscle relaxers to use on a prn basis. My condition is also not surgically reversible, unfortunately.

IF you are considering MMT through a methadone program, please PM me. There are a number of considerations you MUST be prepared for before you enroll--such as the cost. Cost varies by clinic and state, but here it is very expensive--nearly $400 a month and they do not take insurance. Cash only, up front, or you don't your meds that day. Also, be prepared to drive to the clinic EVERY DAY for your dose. Until you are clean from ALL opioids (methadone does not test positive for opioids, so a positive UA would mean you are using another drug) for a number of months and develop some rapport and trust with the clinic, you will not be allowed to have "take-home" doses except on holidays, maybe on Sundays--depends on the clinic's hours of operation. You will get it in liquid form only, have to drink it there, and if you do get to take any doses home, you must return all the empty bottles. DO NOT be tempted to sell it (I don't care how law-abiding a person you are, when you are dependent on methadone and are suddenly faced with not getting your dose because you are broke -vs- selling your methadone for $1/milligram to one of the dozens of people who will ask you daily to do so...you CONSIDER it!) as several people were nailed at my clinic by the Feds and the LEAST amount of time someone got was 3 years in Federal prison. So...not saying you WOULD do this, but we've all been in withdrawal at one time or another...because of the nature of this program and the wide variety of its clientelle, well...the temptation is always there. But if you are willing to jump thru the hoops, it may be a good alternative for you.

By the way, I have NO IDEA why "meth" (which is the slang term for methamphetamine, by the way--NOT methadone) would cause you to have nervousness? It's an opioid, nothing more nefarious than that. Unless you ARE referring to or confusing methadone with methamphetamine?

Happy to help in any way I can! PM if you like.

--------------------
Never underestimate the predictability of stupidity.


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tray1
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Re: Oxycontin & Methadone????? [Re: night_shade]
      #159678 - 05/05/04 10:00 AM

Hey Night,
I guess my wording was quite off, I did not mean a methadone clinic, I meant as pain management, the Doc I am considering seems to favor this medicine as pain mgmt. And yes I mean methadone, did not mean to imply methamphetamines. I guess my fears are based on other peoples comments, etc. I only personally know one person who was weaned off of it and it was in a clinic setting like you described for detox purposes and she did go thru he double hockey sticks. But I trust your judgement as you seem very knowledgeable, I dont even know if my condition would warrant this type of medication but I just want to be prepared before I go to see this Doc. Thank you for the info.

Tray


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herkledeeks
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Reged: 11/12/03
Posts: 63
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Re: Oxycontin & Methadone????? [Re: flea]
      #159752 - 05/05/04 02:03 PM

Methadone blocks opiate receptors in your body, so be careful not to take too much Oxycontin. You may OD.

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night_shade
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Re: Oxycontin & Methadone????? [Re: herkledeeks]
      #159760 - 05/05/04 02:21 PM

Methadone does NOT block opiate receptors. It simply has a high affinity for opiate receptors and will displace other, less potent (for lack of a more descriptive word,) opioids.

The misconception is that it completely "blocks" other opioids and this is NOT true. At high doses of methadone, other narcotics are not as potent as they normally would be, but they still will "penetrate" methadone. The danger lies only in people seeking to get high on heroin or prescription opiates while using moderate to high doses of methadone (50mgs to 100+)...you will overdose before achieving the euphoric affect from opioids.

When used in pain treatment alone or concurrently with other narcotics such as oxycodone, and as prescribed, there is simply NO DANGER WHATSOEVER of overdose.

I really wish people would quit spreading methadone fallacies and inflammatory statements! Please do your research and don't spread the "word on the street!" This is the biggest reason many pain patients are reluctant to utilize methadone as the stigma and misinformation bandied about through MMT and heroin substitution programs has given the drug's pain-relieving qualities a completely bad rep.

--------------------
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flea
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Re: Oxycontin & Methadone????? [Re: tray1]
      #159773 - 05/05/04 03:12 PM

Thanks for the input everyone!! I do not know what I would do without this place sometimes! I mean who else would I have been able to ask this question of, my mom, my dad, my neighbor, NOPE, no one.....and that's why I love all of you SOOOOOOOOOOOOOOOOOOO much!!!!! O.K. enough lovey doveyness (my own made up word obviously!)

First I wanted to say to Pakersfan that I was so shocked to hear you Bombed from half of the 10 mg methaodne pill. I mean, WOW!!! I guess it is surprising because you really were taking what most would probably assume to be a pretty high amount of narcotics to begin with, therefore only 5mg of methadone somehow did not seem like a lot to me, but I guess it effects everyone differently. I never got "bombed" or "knocked out" at all from the methadone. I never felt anything but pain relief, and even that soon faded, as the extent of my pain finally reaered its ugly head.
Although on that note PACKERSFAN......I was so happy to hear that the combo you are now on has worked so well for your pain. I mean really, at the end of the day thats all that really matters, right? So I am really happy for you!

When I was first prescribed the methadone, the dose was initially set at 80mg daily. That was eventually increased to 85mg daily. I was then brought down by 5mg every month, or two. Now keep in mind that I was being prescribed this methadone again, by my family doctor, not through any kind of pain clinic. She had once again taking such a professional risk with me, and continues to do so.

So I had been on the methadone at a decreasing amount for about 8 months when suddenly my recovery took a turn for the worse. Instead of getting stronger and feeling less pain, it seemed as though my pain was increasing week to week. It was not until that first MRI post surgery that my surgeon realized that my recovery would be significantly different than from those without ant of these complications. However this surgeon (one of the best in his field I might add) was completely anti-narcotics. He initially had me on 5mg of vicodin, then switched me to Neurontin, even after the results of my MRI showed major scar tissue was now surrounding and pressing on my nerve, he was still convinced narcotics were not the way to go. Thankfully his anti-methadone stance once again did not move my doctor to give up. If anything after she received the MRI results we then discussed different pain control ideas. ie duragesic (which I tried but sadly I had a horrible allergic reaction to) and then we tried MS Contin, but then ended up trying the Oxycontin and it turned out to be the best thing for my pain, EVER!!!!

Like I said in my first post, even though my tolerance was building, a decrease of the oxycontin every month- 2 months was still not that horrible. And to answer NIGHT_SHADES question regarding what dose of each med I was taking, well its as follows: The Methadone was as mentioned above, at the high, 85mg daily, then I went down to 55mg daily. It was then that I switched over to the duragesic, where I eventually went up to 3- 100 patches and several 25's. I think it was a total of 325-375 as directed.(whatever the crazy little sign for how many milligrams was in each patch were, as it was written on the package.)I think my doctor messed up with that one. She somehow did not do the right conversion, although she does not admit that, but anyway, I was slappin' on far more of those patches then I ever should have been. I am lucky that I had an allergic reactiona and developed such a bad rash under the patches, as I think that rash was the only thing stopping the med on the patch to make it into my blood stream. Strange tot hink that maybe that was my own bodies defense mechanism against maybe too high of dose, I mean, thats strong stuff andis pretty dangerous, you know? Anyway, after 2 weeks with the rashes under each patch, my doctor and I finally realized I better just go off of it all together.

Then I was put on the Oxycontin: I think I started at 270mg daily, and up to 8 of the 5mg oxycodones daily for break through pain.

I am now at 180 of the oxycontin, yet the oxycodones are suprisingly still prescribed as up to 8 daily, with a great emphasis on the "as needed".

Thats where I am at, so as you can imagine, fearing being out of such a high dose of these is pretty scary. I am already 100% out of the 5mg oxycodones. However last month I was prescribed it on a different day, so I am able to get that filled in 7 days, not the now 9 days like for the oxycontin.

So I have really been doing my best to fix my own mess here, and just deal with having to suddenly lower my dose so much, especailly since the main reason I increased it this month to start with was because for some reason my back has been hurting more than ever, which of course only makes all of this that much more unbearable, in every respect.

Luckily I have learned my lesson now! I will never ever take more than I am supposed to without discussing it with my doctor first! As for now, I guess after reading everything that you all wrote, well I think I may just go ahead and take the methadone along with the oxycontins until I can get my next refill. I mean right now I am not only feeling the effects of such a dramatic drop in the amount of milligrams of the oxycodone via the oxycontins and the 5mg oxycodones, but I am also keenly aware of the reason I increased my amounts this month to begin with, and that was my increased back pain. Oh GOD I want to die right now. The pain is so much more profound than it had been with a higher dose (duh!) but all I can think of is how dumb I was in doing that. Did I really believe I could equal my self out before my next refill? Well i was stupid. I am the first to admit that!!!!!

But I am now sorta scared as well. My back is so bad that I am not able to sleep and I can not inrease what few oxycontins I have left or else I will be completely out even sooner, meaning I'd basically be up sh!t creek, if you know what i mean??

So for those of you taking the methadone along with the other narcotics, do you have any "unoffical" advice for how much methadone I should take intermixed with the oxycontins, until my next refll? I know there were a few comments that I should NOT mix the 2 without having a rx that says to do so, but right now I don't really see any other choice. I had already once, when I first got the oxycontins, I was putting them in my weekly pill dispencer and they spilled in the sink. I lost almost 16 of them, and a few others lost part of their coating, meaning if I did take any of them, I woudl get the immediate dose, as I learned the coating is also part of the slow realese function. Therefore my doctor had to give me more. Then several, several months later my husband picked up my oxycodone for me and then went golfing. Somehow, someway he either lost them or someone stole them, but who cared how it happened, bottom lone was 240 - 5mg oxycodones were now GONE, and that was almost an impossible thing for even me to believe, let alone my poor doctor. But I know thats what happened as my husband cant even take an aspirin without getting knocked out, so there was no way he was lying about the missing meds because he wanted them himself, or for any other reason at all. I mean we don't even know anyone in this new town, so what could he possible do with them? He finally realized he screwed up in that he thought he had locked the car but after getting his golf clubs out of the back and having his hands full and his keys back in his pocket, that he did admit that he had not locked the car, therefore meaning someone opened the car door and stole them. He later came clean in saying that his sunglasses and 6 CD's were also gone, but he felt like such a moron at the time that he did not even admit it at first. Well that suc*ed as had he filed a police report it would have been much easier to explain. Without that proof, I just looked like another "drug-seeker" using the same ole' tactics as all others, "some fell down my sink, they got stolen, blah blah blah! I mean whats next, my dog ate them? Geez, I better knock on wood or else that too may happen at the rate I am going,HA!. However for some odd reason my doctor believed in me and trusted me enough to once again fully relace the entire 240 pills. Crazy huh?

So I can not go to her yet again and ask for an early refill. Especially since this time it WAS my own fault, and I did do something that neither she nor the pharmacy would allow, under any circumstances. Heck, especially the pharmacy, as they are always rude to me in there but because it is part of my HMO and is loacted in the same office buiding as my doctor, I have no real choice but to keep going there. They are so strict that unless my doctor SPECIFICALLY changed the dose (increased it) they would not refill it early anyway.

So with all of the basis covered here, can anyone tell me what they would do? If they had an old bottle of about 18, 5mg methadones left, would they take them in ocnjunction with the oxycontins until their next full refill? If so, how much and when? All together, or at different times throughout the day?

Thanks again everyone, and I once again apologize for such a long post!

--------------------
Flea



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night_shade
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Re: Oxycontin & Methadone????? [Re: flea]
      #159814 - 05/05/04 05:08 PM

Flea-

I would continue taking the amount of OxyContin you are taking now to get thru until your next script. Divide the methadone tabs by the number of days you have left til the OC refill and add them to your Oxy daily dose.

At that small of a methadone dose, I would have no concerns of OD. If I understand correctly, you have 7 days left til the refill? If that is the case, take 15mgs of methadone (take it all in one dose, it will be more effective and should last most of the waking hours) for the first 6 days. Then you only have 1 day before the refill without the methadone.

The methadone should significantly help your pain AND hold off the worst of the withdrawal.

Best of luck!

--------------------
Never underestimate the predictability of stupidity.


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