justforu
Newbie
Reged: 01/08/04
Posts: 44
Loc: San Antonio, TX
|
|
HI.I have been on the Bup injections for a week or so now and am finally feeling better. I went to see my doctor and he said something that has me totally confused AGAIN. I am on the Buprenex Injectable (Buprenorphine hydrochloride). My mother went to the dr today with me and she asked him about the class of narcotics that it was. He said that it actually had something in it for addicts that if I took something, like hydro, that I wouldnt feel the effects and it could acctualy make me sick. I thought that was the Sub or the pill version of the Bup. I sure dont want to find out by trying but I was just curious if he just told my mom that because she was being so nosey about it being a narcotic or if that's really true about the Buprenex injections. I must say that after a couple days that shots started helping alot! I guess curious minds want to know. Thanks so much everyone!
|
rockystuart
Enthusiast
Reged: 03/11/04
Posts: 230
Loc: San Fran Bay Area, Calif
|
|
BY sick, he ment that you could go into WD.
Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.
Naxooline is a mu-opiiod antagonist, but is not very active unless injected. Thus if you injuct the combo drug tabs it will not work.
The kappa antagonist action of Bup COULD cause WD by itself , depending on what you have been using.
Probably it is just the DR confusing the WARNINGS for the Subutex (combo) drug, with the BUP inj itself.
|
rockystuart
Enthusiast
Reged: 03/11/04
Posts: 230
Loc: San Fran Bay Area, Calif
|
|
SORRY SORRY SORRY
Subutex is the standalone Bup.
SUBOXONE is the combo drug.
BUP by itself (without naloxone as it SUBOXONE) has been known to cause WD in morph addicted people, primarily due to u-opoid dose changes- 3mg bup inj = 10mg morph = 6=8mg bup sublingal. If you rtaking 60mg mroph/day and cut it down to 10mg morpg (or 3mg buph - then you get WD.
BUT unless your taking 30 hydro/day you probably don't need to worry.
BUT TEMESIC/SUBUTEX (or BUPRONEX inj) will only work for about 3-5 days - leastwise euphoria/analgesia. IT WILL prevent WD if dose is correct.
|
yawkaw3
Pooh-Bah
Reged: 03/22/03
Posts: 1193
|
|
justforu,
I'm sorry to hear you are still with this shmuck doctor.
Quote:
He said that it actually had something in it for addicts that if I took something, like hydro, that I wouldnt feel the effects and it could acctualy make me sick.
Forget everything you've heard about receptors, agonists, and antagonists. I will tell it to you in practical terms.
If you are on bupe, you will not be able to get high on a traditional opiate like hydro or oxy for at least 48 hours. Bupe blocks other opiates from getting you high.
Where this is confusing for some people is with the dose. A .2 mg Temgesic might be no problem to get high soon after, but I guarantee you will not be getting high if you're on an 8 mg Suboxone. So how strong that opiate block effect is depends totally on the dose and how long you've been on it.
You will not go into withdrawal on bupe from taking another opiate, UNLESS it is your first day, and you do not wait long enough between your last dose of regular opiate and starting the bupe. Don't overcomplicate this- if you took an insane amount, it is possible to end up in withdrawal- but we are talking very high doses, and it's a totally individual thing. It won't happen to you unless you dramatically exceed your doctor's orders.
The naloxone has nothing to do with causing withdrawal- hardly any is ingested when you take a Suboxone. It is the bupe itself that has this opiate-block/wd effect. The naloxone is in there to prevent you from shooting it.
I still think you need a new doctor. Tell your mom it's an opiate partial agonist, unless she understands pharmacology, trying to explain the different affinities for opiate receptors and the differences in binding is going to be too much. Just tell her it's a specialized narcotic that isn't really abusable- all she needs to know.
-yawkaw
|
justforu
Newbie
Reged: 01/08/04
Posts: 44
Loc: San Antonio, TX
|
|
Hi Yawkaw, I went ahead and just did the Bup shots because I had them and was desperate to get off of the nasty meds. So far so good  A rough couple of days but I can really say I don't want to take any hydro. Boy all of this can sure be confusing. So if someone stopped Bup and waited 2 days then took hydro would they get high? They wouldnt go into withdrawel? He just really had me confused because I always thought it was the Nalaxone (sp) in the Sub that caused that. Boy, you learn something new every day! lol. I have noticed that the shots have caused alot of bruising in my tummy and im very sore also. Has anyone had that? Now that I know that about the Bup and other opiates not getting in, what if one was in a horrific car accident and had limbs torn off and was on bup? There would be no pain releif at all! Omg my mind wanders a little too much sometimes lmao
|
yawkaw3
Pooh-Bah
Reged: 03/22/03
Posts: 1193
|
|
A lot of people ask the question, "If I'm on bupe- how long do I have to stop taking it so I can get high?"
It depends on your dosage and your unique body chemistry, but the generally accepted rule of thumb is 2-3 days. It can take longer to get even more bang for your buck, but no more than 5-6 days. People and dosages vary though- if you're only on a few .2 Tems a day, there might be hardly any blocking effect at all- everyone's different and has a difference dose that works and a different time period before they can get high or pain relief again.
It's really not something you should experiment with to find out Keep in mind why you got on it in the first place- there's never one last time!
What if you needed dental work, surgery, had an accident, etc.? Welp- bupe does work for pain, in fact it was marketed in America as a painkiller for a while before they started using it for addiction. Might need your dosage increased temporarily, the ER doc should consult with the prescribing doc for the bupe IMO to decide how to get you relief.
-yawkaw
|
justforu
Newbie
Reged: 01/08/04
Posts: 44
Loc: San Antonio, TX
|
|
With the Bupe, I found that I can actually go a day without doing any injections and feel fine. Its very strange. Im guessing because its a long acting med? I sure never felt that way taking the hydro. The only draw back about the injections is its not that easy to go out for the day with injections and amples in hand. You have to find a place to go to administer the bupe and its a pain in the rear but I do think its well worth it. I will be switching to the pill next week. I am not too sure what to expect, if any difference. I am going to do a search. Does the pill work faster?
|
Previous
Index
Next
Threaded
Edit 
Reply 
Quote 
