In most people the higher the APAP ratio to the hydro will make the analgesic effect stronger. But everybody is different, and lots of people are uncomfortable with all that APAP/.tylenol in their livers.
True, It seems that apap does in fact raise the effectivness of a product, but it also puts strain on your liver, like the above post states. It's really really wise to limit your apap intake to 2500mg total in a 24 hour period. This is if you are taking it long term. Most everyone already knows this, but it's something that should be stressed from time to time. I've had a scary run in with hight ALT liver levels, when taking to much apap for a long period of time. It was under 4000mg daily, but I then found out that number mg's is for short periods of time 1-2 weeks.
Good luck and my motto is, the less apap the better..
I personally still get the same pain relief from a product with little to no apap. Just my opinion.
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Does APAP strengthen or weaken oxy-hydro? 
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Re: Does APAP strengthen or weaken oxy-hydro? 