I know that Nexium is much stronger than Prilosec, and if I had a choice, I would get the Nexium (my husband takes it). But because of the price difference, we have sometimes just gotten the Prilosec now, since it most recently is now sold over the counter.

When he is out of Nexium and is feeling awful, I just go ahead and get the over the counter Prilosec and cross my fingers. It usually helps for awhile, but eventually he needs the Nexium again.

Anyway, just a thought.