My pain doctor increased the avinza to 120mg daily. To me it is not as effective as the ms contin. I was on 60mg 3x a day. I had the best pain relief from the 40mg oxycontin but I had been on that dose for about a year. When I told him I thought it was loosing it's effectivness he put me on the ms contin. I would like feedback on anyone experiencing fluid retention from Avinza. I'm having that now & think it might be the medication.