It may just be a figment of my imagination; but I have to agree that the 10/325 mallies seem to help better than the watsons. The reason I say "a figment of my imagination," is because I don't have the same relief when it comes to any other dosage of mallies versus watson... the 10/500 watsons work better than the mallies of the same dosage. Even if it is just all in my mind, what counts is what relieves your own pain most effectively, for whatever reason. One thing I can say for all of the generics, whether it's mallies or watson, both make me more drowsy than the UCB Brand. When I asked a pharmacist about this before, he indicated that it could have something to do with fillers contained in those generics that aren't in the UCB Brand.