PJ,
You've got me a little confused here. I specifically said that "if you're taking 300/400 mg of tramadol AND you are seizure prone, then that's probably a bad idea. It's also probably a bad idea for many other medications".

You are talking about a person taking a HUGE overdose of ultram. All bets are off in that case. I am still waiting for someone to show me a study in human beings that demonstrates a positive correlation between 200 mg ultram/day and seizures. Maybe it's out there, but I haven't seen it.

And as far as evidence goes, yours is antidotal. There probably was a cause and effect relationship between ultram and the seizures, but again, all bets are off on doses that high. My evidence is actually knowing an M.D./Ph.D. with a pain practice who has about 1000 patients on ultram and has never had one get a seizure.

Just about any prescription drug taken in a heavy overdose is going to do bad things to you.

Anyway, no hard feelings at all!
Cheers,
D.